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Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline

The estimated incidence rate of prostate cancer in Africa was 22.0/100,000 in 2016. The International Agency for Research on Cancer (IARC) has cited prostate cancer as a growing health threat in Africa with approximated 28,006 deaths in 2010 and estimated 57,048 deaths in 2030. The exact incidence o...

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Autores principales: Cassell, Ayun, Yunusa, Bashir, Jalloh, Mohamed, Ndoye, Medina, Mbodji, Mouhamadou M., Diallo, Abdourahmane, Kouka, Saint Charles, Labou, Issa, Niang, Lamine, Gueye, Serigne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915139/
https://www.ncbi.nlm.nih.gov/pubmed/31885569
http://dx.doi.org/10.1155/2019/1785428
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author Cassell, Ayun
Yunusa, Bashir
Jalloh, Mohamed
Ndoye, Medina
Mbodji, Mouhamadou M.
Diallo, Abdourahmane
Kouka, Saint Charles
Labou, Issa
Niang, Lamine
Gueye, Serigne M.
author_facet Cassell, Ayun
Yunusa, Bashir
Jalloh, Mohamed
Ndoye, Medina
Mbodji, Mouhamadou M.
Diallo, Abdourahmane
Kouka, Saint Charles
Labou, Issa
Niang, Lamine
Gueye, Serigne M.
author_sort Cassell, Ayun
collection PubMed
description The estimated incidence rate of prostate cancer in Africa was 22.0/100,000 in 2016. The International Agency for Research on Cancer (IARC) has cited prostate cancer as a growing health threat in Africa with approximated 28,006 deaths in 2010 and estimated 57,048 deaths in 2030. The exact incidence of advanced and metastatic prostate cancer is not known in sub-Saharan Africa. Hospital-based reports from the region have shown a rising trend with most patients presenting with advanced or metastatic disease. The management of advanced and metastatic prostate cancer is challenging. The available international guidelines may not be cost-effective for an African population. The most efficient approach in the region has been surgical castration by bilateral orchidectomy or pulpectomy. Medical androgen deprivation therapy is expensive and may not be available. Patients with metastatic castrate-resistant prostate cancer tend to be palliated due to the absence or cost of chemotherapy or second-line androgen deprivation therapy in most of Africa. A cost-effective guideline for developing nations to address the rising burden of advanced prostate cancer is warranted at this moment.
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spelling pubmed-69151392019-12-29 Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline Cassell, Ayun Yunusa, Bashir Jalloh, Mohamed Ndoye, Medina Mbodji, Mouhamadou M. Diallo, Abdourahmane Kouka, Saint Charles Labou, Issa Niang, Lamine Gueye, Serigne M. J Oncol Review Article The estimated incidence rate of prostate cancer in Africa was 22.0/100,000 in 2016. The International Agency for Research on Cancer (IARC) has cited prostate cancer as a growing health threat in Africa with approximated 28,006 deaths in 2010 and estimated 57,048 deaths in 2030. The exact incidence of advanced and metastatic prostate cancer is not known in sub-Saharan Africa. Hospital-based reports from the region have shown a rising trend with most patients presenting with advanced or metastatic disease. The management of advanced and metastatic prostate cancer is challenging. The available international guidelines may not be cost-effective for an African population. The most efficient approach in the region has been surgical castration by bilateral orchidectomy or pulpectomy. Medical androgen deprivation therapy is expensive and may not be available. Patients with metastatic castrate-resistant prostate cancer tend to be palliated due to the absence or cost of chemotherapy or second-line androgen deprivation therapy in most of Africa. A cost-effective guideline for developing nations to address the rising burden of advanced prostate cancer is warranted at this moment. Hindawi 2019-12-05 /pmc/articles/PMC6915139/ /pubmed/31885569 http://dx.doi.org/10.1155/2019/1785428 Text en Copyright © 2019 Ayun Cassell et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cassell, Ayun
Yunusa, Bashir
Jalloh, Mohamed
Ndoye, Medina
Mbodji, Mouhamadou M.
Diallo, Abdourahmane
Kouka, Saint Charles
Labou, Issa
Niang, Lamine
Gueye, Serigne M.
Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title_full Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title_fullStr Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title_full_unstemmed Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title_short Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline
title_sort management of advanced and metastatic prostate cancer: a need for a sub-saharan guideline
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915139/
https://www.ncbi.nlm.nih.gov/pubmed/31885569
http://dx.doi.org/10.1155/2019/1785428
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