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Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?
Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent biochemical step crucially underlies the subsequent biological activity of Se and argues for...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915170/ https://www.ncbi.nlm.nih.gov/pubmed/31845001 http://dx.doi.org/10.1186/s40635-019-0281-y |
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author | Kuganesan, Mathun Samra, Kavitej Evans, Eloise Singer, Mervyn Dyson, Alex |
author_facet | Kuganesan, Mathun Samra, Kavitej Evans, Eloise Singer, Mervyn Dyson, Alex |
author_sort | Kuganesan, Mathun |
collection | PubMed |
description | Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent biochemical step crucially underlies the subsequent biological activity of Se and argues for inclusion of hydrogen selenide as the fourth endogenous gasotransmitter alongside nitric oxide, carbon monoxide and hydrogen sulfide. Endogenously generated hydrogen selenide is incorporated into numerous ‘selenoprotein’ oxidoreductase enzymes, essential for maintaining redox-status homeostasis in health and disease. Direct effects of endogenous hydrogen selenide on cellular and molecular targets are currently unknown. Given exogenously, hydrogen selenide acts as a modulator of metabolism via transient inhibition of mitochondrial cytochrome C oxidase. Here we provide an overview of Se biology, its impact on several physiological systems (immune, endocrine, cardiovascular and metabolic) and its utility as a supplement in acute and critical illness states. We further explore the evidence base supporting its role as the fourth gasotransmitter and propose a strategic case towards generation of novel selenomimetic therapeutics. |
format | Online Article Text |
id | pubmed-6915170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-69151702019-12-30 Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? Kuganesan, Mathun Samra, Kavitej Evans, Eloise Singer, Mervyn Dyson, Alex Intensive Care Med Exp Review Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent biochemical step crucially underlies the subsequent biological activity of Se and argues for inclusion of hydrogen selenide as the fourth endogenous gasotransmitter alongside nitric oxide, carbon monoxide and hydrogen sulfide. Endogenously generated hydrogen selenide is incorporated into numerous ‘selenoprotein’ oxidoreductase enzymes, essential for maintaining redox-status homeostasis in health and disease. Direct effects of endogenous hydrogen selenide on cellular and molecular targets are currently unknown. Given exogenously, hydrogen selenide acts as a modulator of metabolism via transient inhibition of mitochondrial cytochrome C oxidase. Here we provide an overview of Se biology, its impact on several physiological systems (immune, endocrine, cardiovascular and metabolic) and its utility as a supplement in acute and critical illness states. We further explore the evidence base supporting its role as the fourth gasotransmitter and propose a strategic case towards generation of novel selenomimetic therapeutics. Springer International Publishing 2019-12-16 /pmc/articles/PMC6915170/ /pubmed/31845001 http://dx.doi.org/10.1186/s40635-019-0281-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Kuganesan, Mathun Samra, Kavitej Evans, Eloise Singer, Mervyn Dyson, Alex Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title | Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title_full | Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title_fullStr | Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title_full_unstemmed | Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title_short | Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
title_sort | selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915170/ https://www.ncbi.nlm.nih.gov/pubmed/31845001 http://dx.doi.org/10.1186/s40635-019-0281-y |
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