Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts

BACKGROUND: Inflammation is recognized as an important contributor of ischemia/reperfusion (I/R) damage after ischemic stroke. Sphingomyelin synthase 2 (SMS2), the key enzyme for the biosynthesis of sphingomyelin, can function as a critical mediator of inflammation. In the present study, we investig...

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Detalles Bibliográficos
Autores principales: Xue, Jing, Yu, Yang, Zhang, Xiangjian, Zhang, Cong, Zhao, Yanan, Liu, Boyan, Zhang, Lan, Wang, Lina, Chen, Rong, Gao, Xuan, Jiao, Peng, Song, Guohua, Jiang, Xian‐Cheng, Qin, Shucun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915272/
https://www.ncbi.nlm.nih.gov/pubmed/31718447
http://dx.doi.org/10.1161/JAHA.119.012885

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