Compromised Metabolic Reprogramming Is an Early Indicator of CD8(+) T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M. bovis BCG infections rewire metabolic circuits and alter effector functions in lung CD8(+) T cells. As Mtb infection progresses,...

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Detalles Bibliográficos
Autores principales: Russell, Shannon L., Lamprecht, Dirk A., Mandizvo, Tawanda, Jones, Terrence T., Naidoo, Vanessa, Addicott, Kelvin W., Moodley, Chivonne, Ngcobo, Bongani, Crossman, David K., Wells, Gordon, Steyn, Adrie J.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915325/
https://www.ncbi.nlm.nih.gov/pubmed/31825836
http://dx.doi.org/10.1016/j.celrep.2019.11.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915325/
https://www.ncbi.nlm.nih.gov/pubmed/31825836
http://dx.doi.org/10.1016/j.celrep.2019.11.034

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