Cargando…

Compromised Metabolic Reprogramming Is an Early Indicator of CD8(+) T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M. bovis BCG infections rewire metabolic circuits and alter effector functions in lung CD8(+) T cells. As Mtb infection progresses,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Russell, Shannon L., Lamprecht, Dirk A., Mandizvo, Tawanda, Jones, Terrence T., Naidoo, Vanessa, Addicott, Kelvin W., Moodley, Chivonne, Ngcobo, Bongani, Crossman, David K., Wells, Gordon, Steyn, Adrie J.C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915325/ https://www.ncbi.nlm.nih.gov/pubmed/31825836 http://dx.doi.org/10.1016/j.celrep.2019.11.034

Ejemplares similares

Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages
por: Cumming, Bridgette M, et al.
Publicado: (2018)

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
por: Mackenzie, Jared S., et al.
Publicado: (2020)

Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate
por: Willemse, Danicke, et al.
Publicado: (2021)

Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays
por: Cumming, Bridgette M., et al.
Publicado: (2021)

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
por: Lamprecht, Dirk A., et al.
Publicado: (2016)

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis
por: Rahman, Md. Aejazur, et al.
Publicado: (2020)

Mycobacterium tuberculosis arrests host cycle at the G(1)/S transition to establish long term infection
por: Cumming, Bridgette M., et al.
Publicado: (2017)

Correction: Mycobacterium tuberculosis arrests host cycle at the G(1)/S transition to establish long term infection
por: Cumming, Bridgette M., et al.
Publicado: (2017)

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response
por: Singh, Amit, et al.
Publicado: (2009)

The impact of immune checkpoint inhibitors in patients with chronic lymphocytic leukemia (CLL): A protocol for a systematic review and meta-analysis of randomized controlled trials
por: Ntsethe, Aviwe, et al.
Publicado: (2020)

Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques
por: Gough, Maya, et al.
Publicado: (2022)

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis
por: Foo, Caroline S., et al.
Publicado: (2018)

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis
por: Saini, Vikram, et al.
Publicado: (2020)

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis
por: Lupien, Andréanne, et al.
Publicado: (2020)

Mycobacterium tuberculosis H(2)S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility
por: Kunota, Tafara T. R., et al.
Publicado: (2021)

Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis
por: Pacl, Hayden T, et al.
Publicado: (2018)

Mycobacterium tuberculosis-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring
por: Manjeese, Wadzanai, et al.
Publicado: (2021)

Profiling and quantification of pluripotency reprogramming reveal that WNT pathways and cell morphology have to be reprogramed extensively
por: Hu, Kejin, et al.
Publicado: (2020)

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase
por: Cai, Yi, et al.
Publicado: (2021)

Mycobacterium mageritense Pulmonary Disease in Patient with Compromised Immune System
por: Huth, R. Gordon, et al.
Publicado: (2011)

Mycobacterium tuberculosis: Manipulator of Protective Immunity
por: Korb, Vanessa C., et al.
Publicado: (2016)

Role of Ergothioneine in Microbial Physiology and Pathogenesis
por: Cumming, Bridgette M., et al.
Publicado: (2018)

Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection
por: Mendonca, Laura E., et al.
Publicado: (2023)

Light Forge: A Microfluidic DNA Melting-based Tuberculosis Test
por: Mbano, Ian M, et al.
Publicado: (2020)

Partial compartmentalisation of HIV-1 subtype C between lymph nodes, peripheral blood mononuclear cells and plasma
por: Jeewanraj, Neschika, et al.
Publicado: (2023)

Corrigendum to “Partial compartmentalisation of HIV-1 subtype C between lymph nodes, peripheral blood mononuclear cells and plasma” [Virology 582 (2023) 62–70]
por: Jeewanraj, Neschika, et al.
Publicado: (2023)

Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
por: Ntsekhe, Mpiko, et al.
Publicado: (2012)

Redox homeostasis in mycobacteria: the key to tuberculosis control?
por: Kumar, Ashwani, et al.
Publicado: (2011)

Mycobacterium tuberculosis DosS binds H(2)S through its Fe(3+) heme iron to regulate the DosR dormancy regulon
por: Sevalkar, Ritesh R., et al.
Publicado: (2022)

Tissue-resident-like CD4(+) T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung
por: Ogongo, Paul, et al.
Publicado: (2021)

Compromised longevity due to Mycobacterium abscessus pulmonary disease in lungs scarred by tuberculosis
por: Singh, Urvashi B., et al.
Publicado: (2019)

Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis
por: Fernández-Soto, Paulina, et al.
Publicado: (2021)

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance
por: Fahrig-Kamarauskait≑, Jūrate˙, et al.
Publicado: (2020)

Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity
por: Bucşan, Allison N., et al.
Publicado: (2022)

Investigating the risks of cardiovascular disease among premenopausal women using oral contraceptive: a protocol for a systematic review and meta-analysis
por: Fabunmi, Oyesanmi A, et al.
Publicado: (2023)

B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice
por: Chen, Yong, et al.
Publicado: (2023)

SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence
por: Winiecka-Klimek, Marta, et al.
Publicado: (2015)

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
por: Rodel, Hylton E., et al.
Publicado: (2021)

Compromised base excision repair pathway in Mycobacterium tuberculosis imparts superior adaptability in the host
por: Naz, Saba, et al.
Publicado: (2021)

T cell activation and cardiovascular risk in type 2 diabetes mellitus: a protocol for a systematic review and meta-analysis
por: Nyambuya, Tawanda M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8bs4d4ufe2ojlvnh8ei7pk00v0