Synthesis and Antibacterial Properties of Novel ZnMn(2)O(4)–Chitosan Nanocomposites

The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol–gel one-pot reaction was used to synthesize hybrid composites of hausmannite–chitosan (Mn(3)O(4)–CS) and its innovative derivative zinc manganese oxide–chitosan (ZnMn(2)O(4)–CS). Fixed amounts of CS with different metal matrix w/v ratios of 0.5%, 1.0%, 1.5%, and 2.0% for Mn and Zn precursors were used to synthesize ZnMn(2)O(4)–CS hybrid composites. X-ray diffraction analysis indicated the formation of polycrystalline tetragonal-structured ZnMn(2)O(4) with a CS matrix in the hybrids. Fourier-transform infrared spectroscopic analysis confirmed the formation of ZnMn(2)O(4)–CS hybrids. Detailed investigations of the surface modifications were conducted using scanning electron microscopy; micrographs at different magnifications revealed that the composites’ surface changed depending on the ratio of the source materials used to synthesize the ZnMn(2)O(4)–CS hybrids. The antibacterial activity of the Mn(3)O(4)–CS and ZnMn(2)O(4)–CS composites was tested against various bacterial species, including Bacillus subtilis, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The zone of inhibition and minimum inhibitory concentration values were deduced to demonstrate the efficacy of the ZnMn(2)O(4)–CS nanocomposites as antibacterial agents.