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Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bon...

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Autores principales: Levingstone, Tanya J., Herbaj, Simona, Dunne, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915504/
https://www.ncbi.nlm.nih.gov/pubmed/31698700
http://dx.doi.org/10.3390/nano9111570
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author Levingstone, Tanya J.
Herbaj, Simona
Dunne, Nicholas J.
author_facet Levingstone, Tanya J.
Herbaj, Simona
Dunne, Nicholas J.
author_sort Levingstone, Tanya J.
collection PubMed
description Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bone tissue engineering solutions. There has been a recent focus on the use of biomaterial-based nanoparticles for the delivery of therapeutic factors. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. This review provides an extensive overview of the current state-of-the-art relating to the design and synthesis of calcium phosphate nanoparticles as carriers for therapeutic factors, the mechanisms of therapeutic factors’ loading and release, and their application in bone tissue engineering.
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spelling pubmed-69155042019-12-24 Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration Levingstone, Tanya J. Herbaj, Simona Dunne, Nicholas J. Nanomaterials (Basel) Review Bone injuries and diseases constitute a burden both socially and economically, as the consequences of a lack of effective treatments affect both the patients’ quality of life and the costs on the health systems. This impended need has led the research community’s efforts to establish efficacious bone tissue engineering solutions. There has been a recent focus on the use of biomaterial-based nanoparticles for the delivery of therapeutic factors. Among the biomaterials being considered to date, calcium phosphates have emerged as one of the most promising materials for bone repair applications due to their osteoconductivity, osteoinductivity and their ability to be resorbed in the body. Calcium phosphate nanoparticles have received particular attention as non-viral vectors for gene therapy, as factors such as plasmid DNAs, microRNAs (miRNA) and silencing RNA (siRNAs) can be easily incorporated on their surface. Calcium phosphate nanoparticles loaded with therapeutic factors have also been delivered to the site of bone injury using scaffolds and hydrogels. This review provides an extensive overview of the current state-of-the-art relating to the design and synthesis of calcium phosphate nanoparticles as carriers for therapeutic factors, the mechanisms of therapeutic factors’ loading and release, and their application in bone tissue engineering. MDPI 2019-11-06 /pmc/articles/PMC6915504/ /pubmed/31698700 http://dx.doi.org/10.3390/nano9111570 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Levingstone, Tanya J.
Herbaj, Simona
Dunne, Nicholas J.
Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title_full Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title_fullStr Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title_full_unstemmed Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title_short Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration
title_sort calcium phosphate nanoparticles for therapeutic applications in bone regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915504/
https://www.ncbi.nlm.nih.gov/pubmed/31698700
http://dx.doi.org/10.3390/nano9111570
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