R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome

Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 long QT syndrome (LQTS2)-associated mutation (c.1600C > T in KCNH2, p.R534C...

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Detalles Bibliográficos
Autores principales: Mesquita, Fernanda C. P., Arantes, Paulo C., Kasai-Brunswick, Tais H., Araujo, Dayana S., Gubert, Fernanda, Monnerat, Gustavo, Silva dos Santos, Danúbia, Neiman, Gabriel, Leitão, Isabela C., Barbosa, Raiana A. Q., Coutinho, Jorge L., Vaz, Isadora M., dos Santos, Marcus N., Borgonovo, Tamara, Cruz, Fernando E. S., Miriuka, Santiago, Medei, Emiliano H., Campos de Carvalho, Antonio C., Carvalho, Adriana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915575/
https://www.ncbi.nlm.nih.gov/pubmed/31844156
http://dx.doi.org/10.1038/s41598-019-55837-w

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