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Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing
Various nanoscale fabrication techniques are elaborated to form artificial nanoporous/nanochannel membranes to be applied for biosensing: one of the most prevalent is the micro-electromechanical systems (MEMS) compatible focused ion beam (FIB) milling. This technique can be easily adopted in micro-...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915623/ https://www.ncbi.nlm.nih.gov/pubmed/31766129 http://dx.doi.org/10.3390/mi10110774 |
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author | Fürjes, Péter |
author_facet | Fürjes, Péter |
author_sort | Fürjes, Péter |
collection | PubMed |
description | Various nanoscale fabrication techniques are elaborated to form artificial nanoporous/nanochannel membranes to be applied for biosensing: one of the most prevalent is the micro-electromechanical systems (MEMS) compatible focused ion beam (FIB) milling. This technique can be easily adopted in micro- and nanomachining process sequences to develop composite multi-pore structures, although its precision and reproducibility are key points in the case of these thick multi-layered membranes. This work is to demonstrate a comprehensive characterisation of FIB milling to improve the reliability of the fabrication of solid state nanopore arrays with precisely predetermined pore geometries for a targeted molecule type to be recognised. The statistical geometric features of the fabricated nanopores were recorded as the function of the process parameters, and the resulting geometries were analysed in detail by high resolution scanning electron microscope (SEM), transmission electron microscope (TEM) and ion scanning microscopy. Continuous function of the pore diameter evolution rate was derived from the experimental results in the case of different material structures, and compared to former dissentient estimations. The additional metal layer was deposited onto the backside of the membrane and grounded during the ion milling to prevent the electrical charging of dielectric layers. The study proved that the conformity of the pore geometry and the reliability of their fabrication could be improved significantly. The applicability of the developed nanopore arrays for molecule detection was also considered by characterising the pore diameter dependent sensitivity of the membrane impedance modulation based measurement method. |
format | Online Article Text |
id | pubmed-6915623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69156232019-12-24 Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing Fürjes, Péter Micromachines (Basel) Article Various nanoscale fabrication techniques are elaborated to form artificial nanoporous/nanochannel membranes to be applied for biosensing: one of the most prevalent is the micro-electromechanical systems (MEMS) compatible focused ion beam (FIB) milling. This technique can be easily adopted in micro- and nanomachining process sequences to develop composite multi-pore structures, although its precision and reproducibility are key points in the case of these thick multi-layered membranes. This work is to demonstrate a comprehensive characterisation of FIB milling to improve the reliability of the fabrication of solid state nanopore arrays with precisely predetermined pore geometries for a targeted molecule type to be recognised. The statistical geometric features of the fabricated nanopores were recorded as the function of the process parameters, and the resulting geometries were analysed in detail by high resolution scanning electron microscope (SEM), transmission electron microscope (TEM) and ion scanning microscopy. Continuous function of the pore diameter evolution rate was derived from the experimental results in the case of different material structures, and compared to former dissentient estimations. The additional metal layer was deposited onto the backside of the membrane and grounded during the ion milling to prevent the electrical charging of dielectric layers. The study proved that the conformity of the pore geometry and the reliability of their fabrication could be improved significantly. The applicability of the developed nanopore arrays for molecule detection was also considered by characterising the pore diameter dependent sensitivity of the membrane impedance modulation based measurement method. MDPI 2019-11-13 /pmc/articles/PMC6915623/ /pubmed/31766129 http://dx.doi.org/10.3390/mi10110774 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fürjes, Péter Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title | Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title_full | Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title_fullStr | Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title_full_unstemmed | Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title_short | Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing |
title_sort | controlled focused ion beam milling of composite solid state nanopore arrays for molecule sensing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915623/ https://www.ncbi.nlm.nih.gov/pubmed/31766129 http://dx.doi.org/10.3390/mi10110774 |
work_keys_str_mv | AT furjespeter controlledfocusedionbeammillingofcompositesolidstatenanoporearraysformoleculesensing |