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Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis

Background: Treatment of atopic dermatitis and psoriasis in children is difficult due to lack of standardized treatment guidelines and few FDA-approved treatment options. Treatments approved for adults may be used off-label in pediatric patients. Objective: This review evaluates the topical and oral...

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Autores principales: Frantz, Travis, Wright, Ellen G., Balogh, Esther A., Cline, Abigail, Adler-Neal, Adrienne L., Feldman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915686/
https://www.ncbi.nlm.nih.gov/pubmed/31694234
http://dx.doi.org/10.3390/children6110125
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author Frantz, Travis
Wright, Ellen G.
Balogh, Esther A.
Cline, Abigail
Adler-Neal, Adrienne L.
Feldman, Steven R.
author_facet Frantz, Travis
Wright, Ellen G.
Balogh, Esther A.
Cline, Abigail
Adler-Neal, Adrienne L.
Feldman, Steven R.
author_sort Frantz, Travis
collection PubMed
description Background: Treatment of atopic dermatitis and psoriasis in children is difficult due to lack of standardized treatment guidelines and few FDA-approved treatment options. Treatments approved for adults may be used off-label in pediatric patients. Objective: This review evaluates the topical and oral treatment options available, including off-label uses, and provides a basic therapeutic guideline for pediatric atopic dermatitis and psoriasis. Methods: A PubMed review of topical and systemic treatments for pediatric psoriasis and atopic dermatitis with information regarding age, efficacy, dosing, contra-indications, adverse events, and off-label treatments. Results: The search identified seven topical and five systemic treatments that are routinely employed to treat pediatric atopic dermatitis and psoriasis. Limitations: Standardized guidelines regarding treatment choice, dosing, and long-term safety are scarce. Reviews may be subject to ascertainment bias. Conclusions: Current treatment guidelines are based on clinical experience and expert advice with few treatments officially approved for atopic dermatitis and psoriasis in children.
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spelling pubmed-69156862019-12-24 Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis Frantz, Travis Wright, Ellen G. Balogh, Esther A. Cline, Abigail Adler-Neal, Adrienne L. Feldman, Steven R. Children (Basel) Article Background: Treatment of atopic dermatitis and psoriasis in children is difficult due to lack of standardized treatment guidelines and few FDA-approved treatment options. Treatments approved for adults may be used off-label in pediatric patients. Objective: This review evaluates the topical and oral treatment options available, including off-label uses, and provides a basic therapeutic guideline for pediatric atopic dermatitis and psoriasis. Methods: A PubMed review of topical and systemic treatments for pediatric psoriasis and atopic dermatitis with information regarding age, efficacy, dosing, contra-indications, adverse events, and off-label treatments. Results: The search identified seven topical and five systemic treatments that are routinely employed to treat pediatric atopic dermatitis and psoriasis. Limitations: Standardized guidelines regarding treatment choice, dosing, and long-term safety are scarce. Reviews may be subject to ascertainment bias. Conclusions: Current treatment guidelines are based on clinical experience and expert advice with few treatments officially approved for atopic dermatitis and psoriasis in children. MDPI 2019-11-05 /pmc/articles/PMC6915686/ /pubmed/31694234 http://dx.doi.org/10.3390/children6110125 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frantz, Travis
Wright, Ellen G.
Balogh, Esther A.
Cline, Abigail
Adler-Neal, Adrienne L.
Feldman, Steven R.
Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title_full Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title_fullStr Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title_full_unstemmed Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title_short Topical and Oral Therapies for Childhood Atopic Dermatitis and Plaque Psoriasis
title_sort topical and oral therapies for childhood atopic dermatitis and plaque psoriasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915686/
https://www.ncbi.nlm.nih.gov/pubmed/31694234
http://dx.doi.org/10.3390/children6110125
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