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Impacts of Zika emergence in Latin America on endemic dengue transmission

In 2015 and 2016, Zika virus (ZIKV) swept through dengue virus (DENV) endemic areas of Latin America. These viruses are of the same family, share a vector and may interact competitively or synergistically through human immune responses. We examine dengue incidence from Brazil and Colombia before, du...

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Autores principales: Borchering, Rebecca K., Huang, Angkana T., Mier-y-Teran-Romero, Luis, Rojas, Diana P., Rodriguez-Barraquer, Isabel, Katzelnick, Leah C., Martinez, Silvio D., King, Gregory D., Cinkovich, Stephanie C., Lessler, Justin, Cummings, Derek A. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915707/
https://www.ncbi.nlm.nih.gov/pubmed/31844054
http://dx.doi.org/10.1038/s41467-019-13628-x
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author Borchering, Rebecca K.
Huang, Angkana T.
Mier-y-Teran-Romero, Luis
Rojas, Diana P.
Rodriguez-Barraquer, Isabel
Katzelnick, Leah C.
Martinez, Silvio D.
King, Gregory D.
Cinkovich, Stephanie C.
Lessler, Justin
Cummings, Derek A. T.
author_facet Borchering, Rebecca K.
Huang, Angkana T.
Mier-y-Teran-Romero, Luis
Rojas, Diana P.
Rodriguez-Barraquer, Isabel
Katzelnick, Leah C.
Martinez, Silvio D.
King, Gregory D.
Cinkovich, Stephanie C.
Lessler, Justin
Cummings, Derek A. T.
author_sort Borchering, Rebecca K.
collection PubMed
description In 2015 and 2016, Zika virus (ZIKV) swept through dengue virus (DENV) endemic areas of Latin America. These viruses are of the same family, share a vector and may interact competitively or synergistically through human immune responses. We examine dengue incidence from Brazil and Colombia before, during, and after the Zika epidemic. We find evidence that dengue incidence was atypically low in 2017 in both countries. We investigate whether subnational Zika incidence is associated with changes in dengue incidence and find mixed results. Using simulations with multiple assumptions of interactions between DENV and ZIKV, we find cross-protection suppresses incidence of dengue following Zika outbreaks and low periods of dengue incidence are followed by resurgence. Our simulations suggest correlations in DENV and ZIKV reproduction numbers could complicate associations between ZIKV incidence and post-ZIKV DENV incidence and that periods of low dengue incidence are followed by large increases in dengue incidence.
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spelling pubmed-69157072019-12-18 Impacts of Zika emergence in Latin America on endemic dengue transmission Borchering, Rebecca K. Huang, Angkana T. Mier-y-Teran-Romero, Luis Rojas, Diana P. Rodriguez-Barraquer, Isabel Katzelnick, Leah C. Martinez, Silvio D. King, Gregory D. Cinkovich, Stephanie C. Lessler, Justin Cummings, Derek A. T. Nat Commun Article In 2015 and 2016, Zika virus (ZIKV) swept through dengue virus (DENV) endemic areas of Latin America. These viruses are of the same family, share a vector and may interact competitively or synergistically through human immune responses. We examine dengue incidence from Brazil and Colombia before, during, and after the Zika epidemic. We find evidence that dengue incidence was atypically low in 2017 in both countries. We investigate whether subnational Zika incidence is associated with changes in dengue incidence and find mixed results. Using simulations with multiple assumptions of interactions between DENV and ZIKV, we find cross-protection suppresses incidence of dengue following Zika outbreaks and low periods of dengue incidence are followed by resurgence. Our simulations suggest correlations in DENV and ZIKV reproduction numbers could complicate associations between ZIKV incidence and post-ZIKV DENV incidence and that periods of low dengue incidence are followed by large increases in dengue incidence. Nature Publishing Group UK 2019-12-16 /pmc/articles/PMC6915707/ /pubmed/31844054 http://dx.doi.org/10.1038/s41467-019-13628-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Borchering, Rebecca K.
Huang, Angkana T.
Mier-y-Teran-Romero, Luis
Rojas, Diana P.
Rodriguez-Barraquer, Isabel
Katzelnick, Leah C.
Martinez, Silvio D.
King, Gregory D.
Cinkovich, Stephanie C.
Lessler, Justin
Cummings, Derek A. T.
Impacts of Zika emergence in Latin America on endemic dengue transmission
title Impacts of Zika emergence in Latin America on endemic dengue transmission
title_full Impacts of Zika emergence in Latin America on endemic dengue transmission
title_fullStr Impacts of Zika emergence in Latin America on endemic dengue transmission
title_full_unstemmed Impacts of Zika emergence in Latin America on endemic dengue transmission
title_short Impacts of Zika emergence in Latin America on endemic dengue transmission
title_sort impacts of zika emergence in latin america on endemic dengue transmission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915707/
https://www.ncbi.nlm.nih.gov/pubmed/31844054
http://dx.doi.org/10.1038/s41467-019-13628-x
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