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Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo

Cancer cells in culture rely on glutamine as an anaplerotic substrate to replenish tricarboxylic acid (TCA) cycle intermediates that have been consumed. but it is uncertain whether cancers in vivo depend on glutamine for anaplerosis. Here, following in vivo infusions of [(13)C(5)]-glutamine in mice...

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Detalles Bibliográficos
Autores principales:	Zhao, Yiqing, Zhao, Xuan, Chen, Vanessa, Feng, Ying, Wang, Lan, Croniger, Colleen, Conlon, Ronald A., Markowitz, Sanford, Fearon, Eric, Puchowicz, Michelle, Brunengraber, Henri, Hao, Yujun, Wang, Zhenghe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915720/ https://www.ncbi.nlm.nih.gov/pubmed/31844152 http://dx.doi.org/10.1038/s41598-019-55718-2

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