HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge

It is known that granulosa cells (GCs) mediate gonadotropin-induced oocyte meiosis resumption by releasing EGF-like factors in mammals, however, the detailed molecular mechanisms remain unclear. Here, we demonstrate that luteinizing hormone (LH) surge-induced histone deacetylase 3 (HDAC3) downregula...

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Detalles Bibliográficos
Autores principales: Wang, Huarong, Cai, Han, Wang, Xiao, Zhang, Meiling, Liu, Bingying, Chen, Ziqi, Yang, Tingting, Fang, Junshun, Zhang, Yanhao, Liu, Wei, Han, Jun, Guo, Qirui, Zhang, Hua, Wang, Haibin, Xia, Guoliang, Wang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915726/
https://www.ncbi.nlm.nih.gov/pubmed/31844300
http://dx.doi.org/10.1038/s41467-019-13671-8

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