IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

IL-17-producing CD8(+) (Tc17) cells are enriched in active lesions of patients with multiple sclerosis (MS), suggesting a role in the pathogenesis of autoimmunity. Here we show that amelioration of MS by dimethyl fumarate (DMF), a mechanistically elusive drug, associates with suppression of Tc17 cel...

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Detalles Bibliográficos
Autores principales: Lückel, Christina, Picard, Felix, Raifer, Hartmann, Campos Carrascosa, Lucia, Guralnik, Anna, Zhang, Yajuan, Klein, Matthias, Bittner, Stefan, Steffen, Falk, Moos, Sonja, Marini, Federico, Gloury, Renee, Kurschus, Florian C., Chao, Ying-Yin, Bertrams, Wilhelm, Sexl, Veronika, Schmeck, Bernd, Bonetti, Lynn, Grusdat, Melanie, Lohoff, Michael, Zielinski, Christina E., Zipp, Frauke, Kallies, Axel, Brenner, Dirk, Berger, Michael, Bopp, Tobias, Tackenberg, Björn, Huber, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915776/
https://www.ncbi.nlm.nih.gov/pubmed/31844089
http://dx.doi.org/10.1038/s41467-019-13731-z

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