An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAF(V600) mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that e...

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Detalles Bibliográficos
Autores principales: Shen, Shensi, Faouzi, Sara, Bastide, Amandine, Martineau, Sylvain, Malka-Mahieu, Hélène, Fu, Yu, Sun, Xiaoxiao, Mateus, Christine, Routier, Emilie, Roy, Severine, Desaubry, Laurent, André, Fabrice, Eggermont, Alexander, David, Alexandre, Scoazec, Jean-Yves, Vagner, Stéphan, Robert, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915789/
https://www.ncbi.nlm.nih.gov/pubmed/31844050
http://dx.doi.org/10.1038/s41467-019-13360-6

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