Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway

BACKGROUND: MicroRNA (miR)-containing exosomes released by acute myeloid leukemia (AML) cells can be delivered into hematopoietic progenitor cells to suppress normal hematopoiesis. Herein, our study was performed to evaluate the effect of exosomal miR-4532 secreted by AML cells on hematopoiesis of h...

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Detalles Bibliográficos
Autores principales: Zhao, Chen, Du, Feng, Zhao, Yang, Wang, Shanshan, Qi, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915875/
https://www.ncbi.nlm.nih.gov/pubmed/31842997
http://dx.doi.org/10.1186/s13287-019-1475-7

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