Evaluation of off‐target effects of gapmer antisense oligonucleotides using human cells

Antisense oligonucleotide (ASO) has the potential to induce off‐target effects due to complementary binding between the ASO and unintended RNA with a sequence similar to the target RNA. Conventional animal studies cannot be used to assess toxicity induced by off‐target effects because of differences...

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Detalles Bibliográficos
Autores principales: Yoshida, Tokuyuki, Naito, Yuki, Yasuhara, Hidenori, Sasaki, Kiyomi, Kawaji, Hideya, Kawai, Jun, Naito, Mikihiko, Okuda, Haruhiro, Obika, Satoshi, Inoue, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915909/
https://www.ncbi.nlm.nih.gov/pubmed/31637814
http://dx.doi.org/10.1111/gtc.12730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915909/
https://www.ncbi.nlm.nih.gov/pubmed/31637814
http://dx.doi.org/10.1111/gtc.12730

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