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Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle

Radiation resistance is a serious issue in radiotherapy. Increasing evidence indicates that the human gut microbiome plays a role in the development of radiation resistance. Vitamin D is an important supplement for cancer patients treated with radiotherapy. Against this background, this paper review...

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Autores principales: Huang, Ruixue, Xiang, Jing, Zhou, Pingkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915920/
https://www.ncbi.nlm.nih.gov/pubmed/31843023
http://dx.doi.org/10.1186/s13046-019-1499-y
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author Huang, Ruixue
Xiang, Jing
Zhou, Pingkun
author_facet Huang, Ruixue
Xiang, Jing
Zhou, Pingkun
author_sort Huang, Ruixue
collection PubMed
description Radiation resistance is a serious issue in radiotherapy. Increasing evidence indicates that the human gut microbiome plays a role in the development of radiation resistance. Vitamin D is an important supplement for cancer patients treated with radiotherapy. Against this background, this paper reviewed research regarding the associations among vitamin D, microbiota dysbiosis, and radiation resistance. A hypothesis is developed to describe the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes. Radiotherapy changes the composition of the gut microbiota, which in turn influence the serum level of vitamin D, and its distribution and metabolism in the body. Alteration of vitamin D level influences the patient response to radiotherapy, where the underlying mechanisms may be associated with the intestinal microenvironment, immune molecules in the intestines, gut microbiome metabolites, and signaling pathways associated with vitamin D receptors. Our understanding of the contribution of vitamin D and the gut microbiota to radiotherapy outcomes has been increasing gradually. A better understanding of the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes will shed more light on radiation resistance, and also promote the development of new strategies for overcoming it, thus addressing an important challenge associated with the currently available radiotherapy modalities for cancer patients.
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spelling pubmed-69159202019-12-30 Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle Huang, Ruixue Xiang, Jing Zhou, Pingkun J Exp Clin Cancer Res Review Radiation resistance is a serious issue in radiotherapy. Increasing evidence indicates that the human gut microbiome plays a role in the development of radiation resistance. Vitamin D is an important supplement for cancer patients treated with radiotherapy. Against this background, this paper reviewed research regarding the associations among vitamin D, microbiota dysbiosis, and radiation resistance. A hypothesis is developed to describe the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes. Radiotherapy changes the composition of the gut microbiota, which in turn influence the serum level of vitamin D, and its distribution and metabolism in the body. Alteration of vitamin D level influences the patient response to radiotherapy, where the underlying mechanisms may be associated with the intestinal microenvironment, immune molecules in the intestines, gut microbiome metabolites, and signaling pathways associated with vitamin D receptors. Our understanding of the contribution of vitamin D and the gut microbiota to radiotherapy outcomes has been increasing gradually. A better understanding of the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes will shed more light on radiation resistance, and also promote the development of new strategies for overcoming it, thus addressing an important challenge associated with the currently available radiotherapy modalities for cancer patients. BioMed Central 2019-12-16 /pmc/articles/PMC6915920/ /pubmed/31843023 http://dx.doi.org/10.1186/s13046-019-1499-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Huang, Ruixue
Xiang, Jing
Zhou, Pingkun
Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title_full Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title_fullStr Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title_full_unstemmed Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title_short Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
title_sort vitamin d, gut microbiota, and radiation-related resistance: a love-hate triangle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915920/
https://www.ncbi.nlm.nih.gov/pubmed/31843023
http://dx.doi.org/10.1186/s13046-019-1499-y
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