Is KCNH1 mutation related to coronary artery ectasia

BACKGROUND: Coronary artery ectasia (CAE) is an uncommon finding in patients undergoing coronary angiography and acute myocardial infarction is an extremely uncommon condition in the presence of coronary artery ectasia. To date, 50 gene variants associated with coronary artery disease have been iden...

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Autores principales: Noori, Mohammad Rafi, Zhang, Bo, Pan, Lifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915935/
https://www.ncbi.nlm.nih.gov/pubmed/31847810
http://dx.doi.org/10.1186/s12872-019-01276-4
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author Noori, Mohammad Rafi
Zhang, Bo
Pan, Lifei
author_facet Noori, Mohammad Rafi
Zhang, Bo
Pan, Lifei
author_sort Noori, Mohammad Rafi
collection PubMed
description BACKGROUND: Coronary artery ectasia (CAE) is an uncommon finding in patients undergoing coronary angiography and acute myocardial infarction is an extremely uncommon condition in the presence of coronary artery ectasia. To date, 50 gene variants associated with coronary artery disease have been identified, but none appear to be related to coronary artery ectasia. CASE PRESENTATION: This is a rare case of Coronary artery ectasia which is considered to be related to Gene variations in potassium voltage-gated channel subfamily H member 1, KCNH1 (encoding a protein designated ether à go-go, EAG1 or KV10.1). CONCLUSION: Occurrence of Acute myocardial infarction in patient with coronary artery ectasia after diarrhea is a very rare condition and involvement of KCNH1 gene mutation which is described in this case report.
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spelling pubmed-69159352019-12-30 Is KCNH1 mutation related to coronary artery ectasia Noori, Mohammad Rafi Zhang, Bo Pan, Lifei BMC Cardiovasc Disord Case Report BACKGROUND: Coronary artery ectasia (CAE) is an uncommon finding in patients undergoing coronary angiography and acute myocardial infarction is an extremely uncommon condition in the presence of coronary artery ectasia. To date, 50 gene variants associated with coronary artery disease have been identified, but none appear to be related to coronary artery ectasia. CASE PRESENTATION: This is a rare case of Coronary artery ectasia which is considered to be related to Gene variations in potassium voltage-gated channel subfamily H member 1, KCNH1 (encoding a protein designated ether à go-go, EAG1 or KV10.1). CONCLUSION: Occurrence of Acute myocardial infarction in patient with coronary artery ectasia after diarrhea is a very rare condition and involvement of KCNH1 gene mutation which is described in this case report. BioMed Central 2019-12-17 /pmc/articles/PMC6915935/ /pubmed/31847810 http://dx.doi.org/10.1186/s12872-019-01276-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Noori, Mohammad Rafi
Zhang, Bo
Pan, Lifei
Is KCNH1 mutation related to coronary artery ectasia
title Is KCNH1 mutation related to coronary artery ectasia
title_full Is KCNH1 mutation related to coronary artery ectasia
title_fullStr Is KCNH1 mutation related to coronary artery ectasia
title_full_unstemmed Is KCNH1 mutation related to coronary artery ectasia
title_short Is KCNH1 mutation related to coronary artery ectasia
title_sort is kcnh1 mutation related to coronary artery ectasia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915935/
https://www.ncbi.nlm.nih.gov/pubmed/31847810
http://dx.doi.org/10.1186/s12872-019-01276-4
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