STLV-1 as a model for studying HTLV-1 infection

Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a...

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Autores principales: Jégado, Brice, Kashanchi, Fatah, Dutartre, Hélène, Mahieux, Renaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915939/
https://www.ncbi.nlm.nih.gov/pubmed/31843020
http://dx.doi.org/10.1186/s12977-019-0503-0
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author Jégado, Brice
Kashanchi, Fatah
Dutartre, Hélène
Mahieux, Renaud
author_facet Jégado, Brice
Kashanchi, Fatah
Dutartre, Hélène
Mahieux, Renaud
author_sort Jégado, Brice
collection PubMed
description Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As HTLV-1, STLV-1 is the etiological agent of ATL, while no case of TSP/HAM has been described. Given its similarities with HTLV-1, STLV-1 represents a unique tool used for performing clinical studies, vaccine studies as well as basic science.
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spelling pubmed-69159392019-12-30 STLV-1 as a model for studying HTLV-1 infection Jégado, Brice Kashanchi, Fatah Dutartre, Hélène Mahieux, Renaud Retrovirology Review Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epidemiology studies demonstrated that, apart from HTLV-1 subtype A, all human subtypes have a simian homolog. As HTLV-1, STLV-1 is the etiological agent of ATL, while no case of TSP/HAM has been described. Given its similarities with HTLV-1, STLV-1 represents a unique tool used for performing clinical studies, vaccine studies as well as basic science. BioMed Central 2019-12-16 /pmc/articles/PMC6915939/ /pubmed/31843020 http://dx.doi.org/10.1186/s12977-019-0503-0 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Jégado, Brice
Kashanchi, Fatah
Dutartre, Hélène
Mahieux, Renaud
STLV-1 as a model for studying HTLV-1 infection
title STLV-1 as a model for studying HTLV-1 infection
title_full STLV-1 as a model for studying HTLV-1 infection
title_fullStr STLV-1 as a model for studying HTLV-1 infection
title_full_unstemmed STLV-1 as a model for studying HTLV-1 infection
title_short STLV-1 as a model for studying HTLV-1 infection
title_sort stlv-1 as a model for studying htlv-1 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915939/
https://www.ncbi.nlm.nih.gov/pubmed/31843020
http://dx.doi.org/10.1186/s12977-019-0503-0
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