Cargando…
Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies
BACKGROUND: Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916045/ https://www.ncbi.nlm.nih.gov/pubmed/31842922 http://dx.doi.org/10.1186/s13018-019-1495-0 |
_version_ | 1783480150620372992 |
---|---|
author | Lu, Feifan Liu, Pei Zhang, Qidong Wang, Weiguo Guo, Wanshou |
author_facet | Lu, Feifan Liu, Pei Zhang, Qidong Wang, Weiguo Guo, Wanshou |
author_sort | Lu, Feifan |
collection | PubMed |
description | BACKGROUND: Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. METHOD: Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I(2) statistic. RESULT: Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. CONCLUSIONS: This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future. |
format | Online Article Text |
id | pubmed-6916045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69160452019-12-30 Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies Lu, Feifan Liu, Pei Zhang, Qidong Wang, Weiguo Guo, Wanshou J Orthop Surg Res Research Article BACKGROUND: Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. METHOD: Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I(2) statistic. RESULT: Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. CONCLUSIONS: This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future. BioMed Central 2019-12-16 /pmc/articles/PMC6916045/ /pubmed/31842922 http://dx.doi.org/10.1186/s13018-019-1495-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lu, Feifan Liu, Pei Zhang, Qidong Wang, Weiguo Guo, Wanshou Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title | Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title_full | Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title_fullStr | Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title_full_unstemmed | Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title_short | Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
title_sort | association between the polymorphism of il-17a and il-17f gene with knee osteoarthritis risk: a meta-analysis based on case-control studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916045/ https://www.ncbi.nlm.nih.gov/pubmed/31842922 http://dx.doi.org/10.1186/s13018-019-1495-0 |
work_keys_str_mv | AT lufeifan associationbetweenthepolymorphismofil17aandil17fgenewithkneeosteoarthritisriskametaanalysisbasedoncasecontrolstudies AT liupei associationbetweenthepolymorphismofil17aandil17fgenewithkneeosteoarthritisriskametaanalysisbasedoncasecontrolstudies AT zhangqidong associationbetweenthepolymorphismofil17aandil17fgenewithkneeosteoarthritisriskametaanalysisbasedoncasecontrolstudies AT wangweiguo associationbetweenthepolymorphismofil17aandil17fgenewithkneeosteoarthritisriskametaanalysisbasedoncasecontrolstudies AT guowanshou associationbetweenthepolymorphismofil17aandil17fgenewithkneeosteoarthritisriskametaanalysisbasedoncasecontrolstudies |