Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

ABSTRACT: BACKGROUND: Trisomy 21 (T21) is associated with intellectual disability that ranges from mild to profound with an average intellectual quotient of around 50. Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in life, characterized by the presence of se...

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Detalles Bibliográficos
Autores principales: Haertle, Larissa, Müller, Tobias, Lardenoije, Roy, Maierhofer, Anna, Dittrich, Marcus, Riemens, Renzo J. M., Stora, Samantha, Roche, Mathilde, Leber, Markus, Riedel-Heller, Steffi, Wagner, Michael, Scherer, Martin, Ravel, Aimé, Mircher, Clotilde, Cieuta-Walti, Cecile, Durand, Sophie, van de Hove, Daniel L. A., Hoffmann, Per, Ramirez, Alfredo, Haaf, Thomas, El Hajj, Nady, Mégarbané, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916110/
https://www.ncbi.nlm.nih.gov/pubmed/31843015
http://dx.doi.org/10.1186/s13148-019-0787-x

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