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Oral health and plaque microbial profile in juvenile idiopathic arthritis
BACKGROUND: The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). METHODS: A cross-sectional exploratory study...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916162/ https://www.ncbi.nlm.nih.gov/pubmed/31842923 http://dx.doi.org/10.1186/s12969-019-0387-5 |
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author | Grevich, Sriharsha Lee, Peggy Leroux, Brian Ringold, Sarah Darveau, Richard Henstorf, Gretchen Berg, Joel Kim, Amy Velan, Elizabeth Kelly, Joseph Baltuck, Camille Reeves, Anne Leahey, Hannah Hager, Kyle Brittnacher, Mitchell Hayden, Hillary Miller, Samuel McLean, Jeffrey Stevens, Anne |
author_facet | Grevich, Sriharsha Lee, Peggy Leroux, Brian Ringold, Sarah Darveau, Richard Henstorf, Gretchen Berg, Joel Kim, Amy Velan, Elizabeth Kelly, Joseph Baltuck, Camille Reeves, Anne Leahey, Hannah Hager, Kyle Brittnacher, Mitchell Hayden, Hillary Miller, Samuel McLean, Jeffrey Stevens, Anne |
author_sort | Grevich, Sriharsha |
collection | PubMed |
description | BACKGROUND: The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). METHODS: A cross-sectional exploratory study of subjects aged 10–18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing. RESULTS: The study included 85 patients with JIA, 62 dental patients and 11 healthy child controls. JIA patients overall had significantly more gingival inflammation compared to dental patients, as evidenced by bleeding on probing of the gingiva, the most specific sign of active inflammation (p = 0.02). Overall, however, there was a trend towards better dental hygiene in the JIA patients compared to dental patients, based on indices for plaque, decay, and periodontitis. In the JIA patients, plaque microbiota analysis revealed bacteria belonging to genera Haemophilus or Kingella elevated, and Corynebacterium underrepresented. In poly JIA, bacteria belonging to the genus Porphyromonas was overrepresented and Prevotella was underrepresented. CONCLUSION: Increased gingival inflammation in JIA was independent of general oral health, and thus cannot be attributed to poor dental hygiene secondary to disability. The variation of microbial profile in JIA patients could indicate a possible link between gingivitis and synovial inflammation. |
format | Online Article Text |
id | pubmed-6916162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69161622019-12-30 Oral health and plaque microbial profile in juvenile idiopathic arthritis Grevich, Sriharsha Lee, Peggy Leroux, Brian Ringold, Sarah Darveau, Richard Henstorf, Gretchen Berg, Joel Kim, Amy Velan, Elizabeth Kelly, Joseph Baltuck, Camille Reeves, Anne Leahey, Hannah Hager, Kyle Brittnacher, Mitchell Hayden, Hillary Miller, Samuel McLean, Jeffrey Stevens, Anne Pediatr Rheumatol Online J Research Article BACKGROUND: The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). METHODS: A cross-sectional exploratory study of subjects aged 10–18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing. RESULTS: The study included 85 patients with JIA, 62 dental patients and 11 healthy child controls. JIA patients overall had significantly more gingival inflammation compared to dental patients, as evidenced by bleeding on probing of the gingiva, the most specific sign of active inflammation (p = 0.02). Overall, however, there was a trend towards better dental hygiene in the JIA patients compared to dental patients, based on indices for plaque, decay, and periodontitis. In the JIA patients, plaque microbiota analysis revealed bacteria belonging to genera Haemophilus or Kingella elevated, and Corynebacterium underrepresented. In poly JIA, bacteria belonging to the genus Porphyromonas was overrepresented and Prevotella was underrepresented. CONCLUSION: Increased gingival inflammation in JIA was independent of general oral health, and thus cannot be attributed to poor dental hygiene secondary to disability. The variation of microbial profile in JIA patients could indicate a possible link between gingivitis and synovial inflammation. BioMed Central 2019-12-16 /pmc/articles/PMC6916162/ /pubmed/31842923 http://dx.doi.org/10.1186/s12969-019-0387-5 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Grevich, Sriharsha Lee, Peggy Leroux, Brian Ringold, Sarah Darveau, Richard Henstorf, Gretchen Berg, Joel Kim, Amy Velan, Elizabeth Kelly, Joseph Baltuck, Camille Reeves, Anne Leahey, Hannah Hager, Kyle Brittnacher, Mitchell Hayden, Hillary Miller, Samuel McLean, Jeffrey Stevens, Anne Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title_full | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title_fullStr | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title_full_unstemmed | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title_short | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
title_sort | oral health and plaque microbial profile in juvenile idiopathic arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916162/ https://www.ncbi.nlm.nih.gov/pubmed/31842923 http://dx.doi.org/10.1186/s12969-019-0387-5 |
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