Crossing fitness valleys via double substitutions within codons

BACKGROUND: Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N substitutions are affected by purifying selection that elimin...

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Detalles Bibliográficos
Autores principales: Belinky, Frida, Sela, Itamar, Rogozin, Igor B., Koonin, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916188/
https://www.ncbi.nlm.nih.gov/pubmed/31842858
http://dx.doi.org/10.1186/s12915-019-0727-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916188/
https://www.ncbi.nlm.nih.gov/pubmed/31842858
http://dx.doi.org/10.1186/s12915-019-0727-4

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