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Crossing fitness valleys via double substitutions within codons
BACKGROUND: Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N substitutions are affected by purifying selection that elimin...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916188/ https://www.ncbi.nlm.nih.gov/pubmed/31842858 http://dx.doi.org/10.1186/s12915-019-0727-4 |