DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways

BACKGROUND: Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to unders...

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Detalles Bibliográficos
Autores principales: Noreen, Faiza, Küng, Taya, Tornillo, Luigi, Parker, Hannah, Silva, Miguel, Weis, Stefan, Marra, Giancarlo, Rad, Roland, Truninger, Kaspar, Schär, Primo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916434/
https://www.ncbi.nlm.nih.gov/pubmed/31842975
http://dx.doi.org/10.1186/s13148-019-0791-1

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