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C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease

C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B, CLEC‐9A, MelLec, Dectin‐1, and LOX‐1...

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Detalles Bibliográficos
Autores principales: Tone, Kazuya, Stappers, Mark H.T., Willment, Janet A., Brown, Gordon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916577/
https://www.ncbi.nlm.nih.gov/pubmed/31580478
http://dx.doi.org/10.1002/eji.201847536
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author Tone, Kazuya
Stappers, Mark H.T.
Willment, Janet A.
Brown, Gordon D.
author_facet Tone, Kazuya
Stappers, Mark H.T.
Willment, Janet A.
Brown, Gordon D.
author_sort Tone, Kazuya
collection PubMed
description C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B, CLEC‐9A, MelLec, Dectin‐1, and LOX‐1. Reflecting the larger CLR family, the Dectin‐1 cluster of receptors has a broad range of ligands and functions, but importantly, is involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis, and other autoimmune diseases. In this mini‐review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin‐1 cluster CLRs, focussing on their physiological roles and involvement in disease.
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spelling pubmed-69165772019-12-23 C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease Tone, Kazuya Stappers, Mark H.T. Willment, Janet A. Brown, Gordon D. Eur J Immunol Highlights C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B, CLEC‐9A, MelLec, Dectin‐1, and LOX‐1. Reflecting the larger CLR family, the Dectin‐1 cluster of receptors has a broad range of ligands and functions, but importantly, is involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis, and other autoimmune diseases. In this mini‐review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin‐1 cluster CLRs, focussing on their physiological roles and involvement in disease. John Wiley and Sons Inc. 2019-11-13 2019-12 /pmc/articles/PMC6916577/ /pubmed/31580478 http://dx.doi.org/10.1002/eji.201847536 Text en © 2019 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Highlights
Tone, Kazuya
Stappers, Mark H.T.
Willment, Janet A.
Brown, Gordon D.
C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title_full C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title_fullStr C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title_full_unstemmed C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title_short C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
title_sort c‐type lectin receptors of the dectin‐1 cluster: physiological roles and involvement in disease
topic Highlights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916577/
https://www.ncbi.nlm.nih.gov/pubmed/31580478
http://dx.doi.org/10.1002/eji.201847536
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