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Virus‐like particles for vaccination against cancer
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of several infectious diseases and expectedly prevent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916610/ https://www.ncbi.nlm.nih.gov/pubmed/31456339 http://dx.doi.org/10.1002/wnan.1579 |
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author | Mohsen, Mona O. Speiser, Daniel E. Knuth, Alexander Bachmann, Martin F. |
author_facet | Mohsen, Mona O. Speiser, Daniel E. Knuth, Alexander Bachmann, Martin F. |
author_sort | Mohsen, Mona O. |
collection | PubMed |
description | Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of several infectious diseases and expectedly preventing cervical cancer caused by human papilloma virus. In contrast to these broad successes of disease prevention, therapeutic cancer vaccines remain to demonstrate clinical benefit. Yet, several preclinical and clinical trials have revealed promising results and are paving the way for medical breakthroughs. This study reviews and discusses the recent preclinical development and clinical trials in this field. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology |
format | Online Article Text |
id | pubmed-6916610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69166102019-12-23 Virus‐like particles for vaccination against cancer Mohsen, Mona O. Speiser, Daniel E. Knuth, Alexander Bachmann, Martin F. Wiley Interdiscip Rev Nanomed Nanobiotechnol Advanced Reviews Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of several infectious diseases and expectedly preventing cervical cancer caused by human papilloma virus. In contrast to these broad successes of disease prevention, therapeutic cancer vaccines remain to demonstrate clinical benefit. Yet, several preclinical and clinical trials have revealed promising results and are paving the way for medical breakthroughs. This study reviews and discusses the recent preclinical development and clinical trials in this field. This article is categorized under: Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology John Wiley & Sons, Inc. 2019-08-27 2020 /pmc/articles/PMC6916610/ /pubmed/31456339 http://dx.doi.org/10.1002/wnan.1579 Text en © 2019 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Advanced Reviews Mohsen, Mona O. Speiser, Daniel E. Knuth, Alexander Bachmann, Martin F. Virus‐like particles for vaccination against cancer |
title | Virus‐like particles for vaccination against cancer |
title_full | Virus‐like particles for vaccination against cancer |
title_fullStr | Virus‐like particles for vaccination against cancer |
title_full_unstemmed | Virus‐like particles for vaccination against cancer |
title_short | Virus‐like particles for vaccination against cancer |
title_sort | virus‐like particles for vaccination against cancer |
topic | Advanced Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916610/ https://www.ncbi.nlm.nih.gov/pubmed/31456339 http://dx.doi.org/10.1002/wnan.1579 |
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