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Current Understanding of Circular RNAs in Gastric Cancer

Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Advanced diagnosis and high rates of relapse and metastasis are associated with the poor prognosis of this disease. GC has a complex etiopathogenesis of which the underlying mechanisms remain to be explored. Studie...

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Autores principales: Tang, Xiaohuan, Zhu, Jiaming, Liu, Yuanda, Chen, Chao, Liu, Tianzhou, Liu, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916696/
https://www.ncbi.nlm.nih.gov/pubmed/31853202
http://dx.doi.org/10.2147/CMAR.S223204
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author Tang, Xiaohuan
Zhu, Jiaming
Liu, Yuanda
Chen, Chao
Liu, Tianzhou
Liu, Jingjing
author_facet Tang, Xiaohuan
Zhu, Jiaming
Liu, Yuanda
Chen, Chao
Liu, Tianzhou
Liu, Jingjing
author_sort Tang, Xiaohuan
collection PubMed
description Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Advanced diagnosis and high rates of relapse and metastasis are associated with the poor prognosis of this disease. GC has a complex etiopathogenesis of which the underlying mechanisms remain to be explored. Studies on circular RNAs (circRNAs), noncoding RNAs that may be potential targets in GC, have made substantial progress over the past few years. CircRNAs exert important effects on the onset and progression of GC. Hence, this article aims to summarize the findings of recent studies of circRNAs related to GC and to describe the underlying mechanisms and potential applications. The findings indicate that circRNAs participate in GC regulation, proliferation, invasion, and metastasis through regulating microRNAs, proteins, genes, and signaling pathways. In addition, dysregulated circRNAs may be used as novel diagnostic and prognostic biomarkers or therapeutic targets. This review is expected to facilitate a better understanding of GC, and it suggests novel circRNA-based methods to inhibit or prevent GC.
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spelling pubmed-69166962019-12-18 Current Understanding of Circular RNAs in Gastric Cancer Tang, Xiaohuan Zhu, Jiaming Liu, Yuanda Chen, Chao Liu, Tianzhou Liu, Jingjing Cancer Manag Res Review Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Advanced diagnosis and high rates of relapse and metastasis are associated with the poor prognosis of this disease. GC has a complex etiopathogenesis of which the underlying mechanisms remain to be explored. Studies on circular RNAs (circRNAs), noncoding RNAs that may be potential targets in GC, have made substantial progress over the past few years. CircRNAs exert important effects on the onset and progression of GC. Hence, this article aims to summarize the findings of recent studies of circRNAs related to GC and to describe the underlying mechanisms and potential applications. The findings indicate that circRNAs participate in GC regulation, proliferation, invasion, and metastasis through regulating microRNAs, proteins, genes, and signaling pathways. In addition, dysregulated circRNAs may be used as novel diagnostic and prognostic biomarkers or therapeutic targets. This review is expected to facilitate a better understanding of GC, and it suggests novel circRNA-based methods to inhibit or prevent GC. Dove 2019-12-13 /pmc/articles/PMC6916696/ /pubmed/31853202 http://dx.doi.org/10.2147/CMAR.S223204 Text en © 2019 Tang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tang, Xiaohuan
Zhu, Jiaming
Liu, Yuanda
Chen, Chao
Liu, Tianzhou
Liu, Jingjing
Current Understanding of Circular RNAs in Gastric Cancer
title Current Understanding of Circular RNAs in Gastric Cancer
title_full Current Understanding of Circular RNAs in Gastric Cancer
title_fullStr Current Understanding of Circular RNAs in Gastric Cancer
title_full_unstemmed Current Understanding of Circular RNAs in Gastric Cancer
title_short Current Understanding of Circular RNAs in Gastric Cancer
title_sort current understanding of circular rnas in gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916696/
https://www.ncbi.nlm.nih.gov/pubmed/31853202
http://dx.doi.org/10.2147/CMAR.S223204
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