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A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls

Resting-state functional connectivity (rsFC) is an emerging means of understanding the neurobiology of combat-related post-traumatic stress disorder (PTSD). However, most rsFC studies to date have limited focus to cognitively related intrinsic connectivity networks (ICNs), have not applied data-driv...

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Autores principales: Vanasse, Thomas J, Franklin, Crystal, Salinas, Felipe S, Ramage, Amy E, Calhoun, Vince D, Robinson, Paul C, Kok, Mitchell, Peterson, Alan L, Mintz, Jim, Litz, Brett T, Young-McCaughan, Stacey, Resick, Patricia A, Fox, Peter T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917024/
https://www.ncbi.nlm.nih.gov/pubmed/31588508
http://dx.doi.org/10.1093/scan/nsz072
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author Vanasse, Thomas J
Franklin, Crystal
Salinas, Felipe S
Ramage, Amy E
Calhoun, Vince D
Robinson, Paul C
Kok, Mitchell
Peterson, Alan L
Mintz, Jim
Litz, Brett T
Young-McCaughan, Stacey
Resick, Patricia A
Fox, Peter T
author_facet Vanasse, Thomas J
Franklin, Crystal
Salinas, Felipe S
Ramage, Amy E
Calhoun, Vince D
Robinson, Paul C
Kok, Mitchell
Peterson, Alan L
Mintz, Jim
Litz, Brett T
Young-McCaughan, Stacey
Resick, Patricia A
Fox, Peter T
author_sort Vanasse, Thomas J
collection PubMed
description Resting-state functional connectivity (rsFC) is an emerging means of understanding the neurobiology of combat-related post-traumatic stress disorder (PTSD). However, most rsFC studies to date have limited focus to cognitively related intrinsic connectivity networks (ICNs), have not applied data-driven methodologies or have disregarded the effect of combat exposure. In this study, we predicted that group independent component analysis (GICA) would reveal group-wise differences in rsFC across 50 active duty service members with PTSD, 28 combat-exposed controls (CEC), and 25 civilian controls without trauma exposure (CC). Intranetwork connectivity differences were identified across 11 ICNs, yet combat-exposed groups were indistinguishable in PTSD vs CEC contrasts. Both PTSD and CEC demonstrated anatomically diffuse differences in the Auditory Vigilance and Sensorimotor networks compared to CC. However, intranetwork connectivity in a subset of three regions was associated with PTSD symptom severity among executive (left insula; ventral anterior cingulate) and right Fronto-Parietal (perigenual cingulate) networks. Furthermore, we found that increased temporal synchronization among visuospatial and sensorimotor networks was associated with worse avoidance symptoms in PTSD. Longitudinal neuroimaging studies in combat-exposed cohorts can further parse PTSD-related, combat stress-related or adaptive rsFC changes ensuing from combat.
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spelling pubmed-69170242019-12-20 A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls Vanasse, Thomas J Franklin, Crystal Salinas, Felipe S Ramage, Amy E Calhoun, Vince D Robinson, Paul C Kok, Mitchell Peterson, Alan L Mintz, Jim Litz, Brett T Young-McCaughan, Stacey Resick, Patricia A Fox, Peter T Soc Cogn Affect Neurosci Original Article Resting-state functional connectivity (rsFC) is an emerging means of understanding the neurobiology of combat-related post-traumatic stress disorder (PTSD). However, most rsFC studies to date have limited focus to cognitively related intrinsic connectivity networks (ICNs), have not applied data-driven methodologies or have disregarded the effect of combat exposure. In this study, we predicted that group independent component analysis (GICA) would reveal group-wise differences in rsFC across 50 active duty service members with PTSD, 28 combat-exposed controls (CEC), and 25 civilian controls without trauma exposure (CC). Intranetwork connectivity differences were identified across 11 ICNs, yet combat-exposed groups were indistinguishable in PTSD vs CEC contrasts. Both PTSD and CEC demonstrated anatomically diffuse differences in the Auditory Vigilance and Sensorimotor networks compared to CC. However, intranetwork connectivity in a subset of three regions was associated with PTSD symptom severity among executive (left insula; ventral anterior cingulate) and right Fronto-Parietal (perigenual cingulate) networks. Furthermore, we found that increased temporal synchronization among visuospatial and sensorimotor networks was associated with worse avoidance symptoms in PTSD. Longitudinal neuroimaging studies in combat-exposed cohorts can further parse PTSD-related, combat stress-related or adaptive rsFC changes ensuing from combat. Oxford University Press 2019-10-07 /pmc/articles/PMC6917024/ /pubmed/31588508 http://dx.doi.org/10.1093/scan/nsz072 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vanasse, Thomas J
Franklin, Crystal
Salinas, Felipe S
Ramage, Amy E
Calhoun, Vince D
Robinson, Paul C
Kok, Mitchell
Peterson, Alan L
Mintz, Jim
Litz, Brett T
Young-McCaughan, Stacey
Resick, Patricia A
Fox, Peter T
A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title_full A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title_fullStr A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title_full_unstemmed A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title_short A resting-state network comparison of combat-related PTSD with combat-exposed and civilian controls
title_sort resting-state network comparison of combat-related ptsd with combat-exposed and civilian controls
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917024/
https://www.ncbi.nlm.nih.gov/pubmed/31588508
http://dx.doi.org/10.1093/scan/nsz072
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