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HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is abe...

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Detalles Bibliográficos
Autores principales:	Luo, Huacheng, Zhu, Ganqian, Xu, Jianfeng, Lai, Qian, Yan, Bowen, Guo, Ying, Fung, Tsz Kan, Zeisig, Bernd B., Cui, Ya, Zha, Jie, Cogle, Christopher, Wang, Fei, Xu, Bing, Yang, Feng-Chun, Li, Wei, So, Chi Wai Eric, Qiu, Yi, Xu, Mingjiang, Huang, Suming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917035/ https://www.ncbi.nlm.nih.gov/pubmed/31786140 http://dx.doi.org/10.1016/j.ccell.2019.10.011

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