Cargando…
A comparison of mechanistic signaling pathway activity analysis methods
Understanding the aspects of cell functionality that account for disease mechanisms or drug modes of action is a main challenge for precision medicine. Classical gene-based approaches ignore the modular nature of most human traits, whereas conventional pathway enrichment approaches produce only illu...
Autores principales: | Amadoz, Alicia, Hidalgo, Marta R, Çubuk, Cankut, Carbonell-Caballero, José, Dopazo, Joaquín |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917216/ https://www.ncbi.nlm.nih.gov/pubmed/29868818 http://dx.doi.org/10.1093/bib/bby040 |
Ejemplares similares
-
Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
por: Hidalgo, Marta R., et al.
Publicado: (2018) -
High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
por: Hidalgo, Marta R., et al.
Publicado: (2016) -
Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
por: Salavert, Francisco, et al.
Publicado: (2016) -
Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models
por: Çubuk, Cankut, et al.
Publicado: (2019) -
Reference genome assessment from a population scale perspective: an accurate profile of variability and noise
por: Carbonell-Caballero, José, et al.
Publicado: (2017)