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Mid‐life and late‐life vascular risk factor burden and neuropathology in old age
OBJECTIVE: To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. METHODS: We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. O...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917310/ https://www.ncbi.nlm.nih.gov/pubmed/31691546 http://dx.doi.org/10.1002/acn3.50936 |
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author | Conner, Sarah C. Pase, Matthew P. Carneiro, Herman Raman, Mekala R. McKee, Ann C. Alvarez, Victor E. Walker, Jamie M. Satizabal, Claudia L. Himali, Jayandra J. Stein, Thor D. Beiser, Alexa Seshadri, Sudha |
author_facet | Conner, Sarah C. Pase, Matthew P. Carneiro, Herman Raman, Mekala R. McKee, Ann C. Alvarez, Victor E. Walker, Jamie M. Satizabal, Claudia L. Himali, Jayandra J. Stein, Thor D. Beiser, Alexa Seshadri, Sudha |
author_sort | Conner, Sarah C. |
collection | PubMed |
description | OBJECTIVE: To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. METHODS: We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. RESULTS: The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). INTERPRETATION: Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death. |
format | Online Article Text |
id | pubmed-6917310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69173102019-12-23 Mid‐life and late‐life vascular risk factor burden and neuropathology in old age Conner, Sarah C. Pase, Matthew P. Carneiro, Herman Raman, Mekala R. McKee, Ann C. Alvarez, Victor E. Walker, Jamie M. Satizabal, Claudia L. Himali, Jayandra J. Stein, Thor D. Beiser, Alexa Seshadri, Sudha Ann Clin Transl Neurol Research Articles OBJECTIVE: To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. METHODS: We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. RESULTS: The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). INTERPRETATION: Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death. John Wiley and Sons Inc. 2019-11-05 /pmc/articles/PMC6917310/ /pubmed/31691546 http://dx.doi.org/10.1002/acn3.50936 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Conner, Sarah C. Pase, Matthew P. Carneiro, Herman Raman, Mekala R. McKee, Ann C. Alvarez, Victor E. Walker, Jamie M. Satizabal, Claudia L. Himali, Jayandra J. Stein, Thor D. Beiser, Alexa Seshadri, Sudha Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title_full | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title_fullStr | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title_full_unstemmed | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title_short | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
title_sort | mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917310/ https://www.ncbi.nlm.nih.gov/pubmed/31691546 http://dx.doi.org/10.1002/acn3.50936 |
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