Children with Narcolepsy type 1 have increased T‐cell responses to orexins

Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4(+) and CD8(+) T‐cells in response to orexins in 27 children with NT1 compared...

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Detalles Bibliográficos
Autores principales: Cogswell, Andrew C., Maski, Kiran, Scammell, Thomas E., Tucker, Dominique, Orban, Zachary S., Koralnik, Igor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917326/
https://www.ncbi.nlm.nih.gov/pubmed/31730293
http://dx.doi.org/10.1002/acn3.50908
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author Cogswell, Andrew C.
Maski, Kiran
Scammell, Thomas E.
Tucker, Dominique
Orban, Zachary S.
Koralnik, Igor J.
author_facet Cogswell, Andrew C.
Maski, Kiran
Scammell, Thomas E.
Tucker, Dominique
Orban, Zachary S.
Koralnik, Igor J.
author_sort Cogswell, Andrew C.
collection PubMed
description Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4(+) and CD8(+) T‐cells in response to orexins in 27 children with NT1 compared to 15 healthy control children. Conversely, no such difference was observed between 14 NT1 and 16 HC adults. In addition, priming with flu peptides amplified the T‐cell response to orexins in children with NT1. Our data suggests that NT1 may be caused by an autoimmune T‐cell response to orexins, possibly triggered by flu antigens.
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spelling pubmed-69173262019-12-23 Children with Narcolepsy type 1 have increased T‐cell responses to orexins Cogswell, Andrew C. Maski, Kiran Scammell, Thomas E. Tucker, Dominique Orban, Zachary S. Koralnik, Igor J. Ann Clin Transl Neurol Brief Communications Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4(+) and CD8(+) T‐cells in response to orexins in 27 children with NT1 compared to 15 healthy control children. Conversely, no such difference was observed between 14 NT1 and 16 HC adults. In addition, priming with flu peptides amplified the T‐cell response to orexins in children with NT1. Our data suggests that NT1 may be caused by an autoimmune T‐cell response to orexins, possibly triggered by flu antigens. John Wiley and Sons Inc. 2019-11-15 /pmc/articles/PMC6917326/ /pubmed/31730293 http://dx.doi.org/10.1002/acn3.50908 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Cogswell, Andrew C.
Maski, Kiran
Scammell, Thomas E.
Tucker, Dominique
Orban, Zachary S.
Koralnik, Igor J.
Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title_full Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title_fullStr Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title_full_unstemmed Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title_short Children with Narcolepsy type 1 have increased T‐cell responses to orexins
title_sort children with narcolepsy type 1 have increased t‐cell responses to orexins
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917326/
https://www.ncbi.nlm.nih.gov/pubmed/31730293
http://dx.doi.org/10.1002/acn3.50908
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