MEFV gene mutations in neuro‐Behçet's disease and neuro‐Sweet disease

Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD). We investigated MEFV genes and clinical features i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishikawa, Hidehiro, Shindo, Akihiro, Ii, Yuichiro, Kishida, Dai, Niwa, Atsushi, Nishiguchi, Yamato, Matsuura, Keita, Kato, Natsuko, Mizutani, Akane, Tachibana, Kei, Hirata, Yoshinori, Matsuyama, Hirofumi, Ogawa‐Ito, Ai, Taniguchi, Akira, Tomimoto, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917328/
https://www.ncbi.nlm.nih.gov/pubmed/31682063
http://dx.doi.org/10.1002/acn3.50937
Descripción
Sumario:Mediterranean fever (MEFV) gene mutations are associated with familial Mediterranean fever (FMF). Recent studies have suggested that MEFV gene mutations may act as disease modifiers in neuro‐Behçet's (NBD) disease and neuro‐Sweet disease (NSD). We investigated MEFV genes and clinical features in 17 patients with NBD or NSD. MEFV gene mutations were frequently observed (70.6%). Headaches and exertional leg pain were associated with MEFV gene mutations (P < 0.05). Moreover, higher frequency of white matter lesions without sites predilection (P < 0.05) and non‐parenchymal lesions (P < 0.05) were also observed. MEFV gene mutations may be associated with particular findings and lesion sites.

Ejemplares similares