Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression

We examined the effects of slow‐pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI‐based realistic head model was constructed for each subject and co‐registered with 256‐channel dense EEG (dEEG). Interictal spikes...

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Detalles Bibliográficos
Autores principales: Holmes, Mark D., Feng, Rui, Wise, Mackenzie V., Ma, Chengxin, Ramon, Ceon, Wu, Jinsong, Luu, Phan, Hou, Jidong, Pan, Li, Tucker, Don M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917336/
https://www.ncbi.nlm.nih.gov/pubmed/31709777
http://dx.doi.org/10.1002/acn3.50934
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author Holmes, Mark D.
Feng, Rui
Wise, Mackenzie V.
Ma, Chengxin
Ramon, Ceon
Wu, Jinsong
Luu, Phan
Hou, Jidong
Pan, Li
Tucker, Don M.
author_facet Holmes, Mark D.
Feng, Rui
Wise, Mackenzie V.
Ma, Chengxin
Ramon, Ceon
Wu, Jinsong
Luu, Phan
Hou, Jidong
Pan, Li
Tucker, Don M.
author_sort Holmes, Mark D.
collection PubMed
description We examined the effects of slow‐pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI‐based realistic head model was constructed for each subject and co‐registered with 256‐channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long‐term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.
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spelling pubmed-69173362019-12-23 Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression Holmes, Mark D. Feng, Rui Wise, Mackenzie V. Ma, Chengxin Ramon, Ceon Wu, Jinsong Luu, Phan Hou, Jidong Pan, Li Tucker, Don M. Ann Clin Transl Neurol Brief Communications We examined the effects of slow‐pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI‐based realistic head model was constructed for each subject and co‐registered with 256‐channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long‐term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges. John Wiley and Sons Inc. 2019-11-11 /pmc/articles/PMC6917336/ /pubmed/31709777 http://dx.doi.org/10.1002/acn3.50934 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Holmes, Mark D.
Feng, Rui
Wise, Mackenzie V.
Ma, Chengxin
Ramon, Ceon
Wu, Jinsong
Luu, Phan
Hou, Jidong
Pan, Li
Tucker, Don M.
Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title_full Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title_fullStr Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title_full_unstemmed Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title_short Safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
title_sort safety of slow‐pulsed transcranial electrical stimulation in acute spike suppression
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917336/
https://www.ncbi.nlm.nih.gov/pubmed/31709777
http://dx.doi.org/10.1002/acn3.50934
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