Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants

OBJECTIVE: To evaluate the association of ibuprofen exposure with the risk of bronchopulmonary dysplasia (BPD) in extremely premature infants. STUDY DESIGN: This was a retrospective study of all extremely premature infants admitted to a tertiary unit from 2016 to 2018. RESULTS: A total of 203 extrem...

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Autores principales: Chen, Xueyu, Qiu, Xiaomei, Sun, Panpan, Lin, Yanqing, Huang, Zhifeng, Yang, Chuanzhong, Walther, Frans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917570/
https://www.ncbi.nlm.nih.gov/pubmed/31391526
http://dx.doi.org/10.1038/s41372-019-0444-4
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author Chen, Xueyu
Qiu, Xiaomei
Sun, Panpan
Lin, Yanqing
Huang, Zhifeng
Yang, Chuanzhong
Walther, Frans J.
author_facet Chen, Xueyu
Qiu, Xiaomei
Sun, Panpan
Lin, Yanqing
Huang, Zhifeng
Yang, Chuanzhong
Walther, Frans J.
author_sort Chen, Xueyu
collection PubMed
description OBJECTIVE: To evaluate the association of ibuprofen exposure with the risk of bronchopulmonary dysplasia (BPD) in extremely premature infants. STUDY DESIGN: This was a retrospective study of all extremely premature infants admitted to a tertiary unit from 2016 to 2018. RESULTS: A total of 203 extremely premature infants were included in this study. The rate of BPD was significantly higher in infants with early exposure to ibuprofen (42.5%) compared to infants with no exposure (21.6%, P = 0.001). After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166–4.522, p = 0.016). Further analysis showed a trend towards higher risk of BPD in infants with successful patent ductus arteriosus (PDA) closure after ibuprofen treatment (32.3%) compared to non-treated infants (20.2%, p = 0.162). CONCLUSION: Our findings suggest that ibuprofen exposure may contribute to the occurrence of BPD in extremely preterm infants.
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spelling pubmed-69175702019-12-20 Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants Chen, Xueyu Qiu, Xiaomei Sun, Panpan Lin, Yanqing Huang, Zhifeng Yang, Chuanzhong Walther, Frans J. J Perinatol Article OBJECTIVE: To evaluate the association of ibuprofen exposure with the risk of bronchopulmonary dysplasia (BPD) in extremely premature infants. STUDY DESIGN: This was a retrospective study of all extremely premature infants admitted to a tertiary unit from 2016 to 2018. RESULTS: A total of 203 extremely premature infants were included in this study. The rate of BPD was significantly higher in infants with early exposure to ibuprofen (42.5%) compared to infants with no exposure (21.6%, P = 0.001). After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166–4.522, p = 0.016). Further analysis showed a trend towards higher risk of BPD in infants with successful patent ductus arteriosus (PDA) closure after ibuprofen treatment (32.3%) compared to non-treated infants (20.2%, p = 0.162). CONCLUSION: Our findings suggest that ibuprofen exposure may contribute to the occurrence of BPD in extremely preterm infants. Nature Publishing Group US 2019-08-07 2020 /pmc/articles/PMC6917570/ /pubmed/31391526 http://dx.doi.org/10.1038/s41372-019-0444-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Xueyu
Qiu, Xiaomei
Sun, Panpan
Lin, Yanqing
Huang, Zhifeng
Yang, Chuanzhong
Walther, Frans J.
Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title_full Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title_fullStr Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title_full_unstemmed Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title_short Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
title_sort neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917570/
https://www.ncbi.nlm.nih.gov/pubmed/31391526
http://dx.doi.org/10.1038/s41372-019-0444-4
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