Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker

Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen receptors. Interleukin-7 (IL-7) and thymic stromal...

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Detalles Bibliográficos
Autores principales: Sheikh, Abdalla, Abraham, Ninan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917604/
https://www.ncbi.nlm.nih.gov/pubmed/31921158
http://dx.doi.org/10.3389/fimmu.2019.02897
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author Sheikh, Abdalla
Abraham, Ninan
author_facet Sheikh, Abdalla
Abraham, Ninan
author_sort Sheikh, Abdalla
collection PubMed
description Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen receptors. Interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP) are cytokines that engage the IL-7Rα and have major roles in dictating the fate of ILCs. Recent advances in the field have revealed transcriptional programs associated with ILC development and function. In this article, we will review recent studies of the role of IL-7 and TSLP in ILC development and function during infection and inflammation.
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spelling pubmed-69176042020-01-09 Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker Sheikh, Abdalla Abraham, Ninan Front Immunol Immunology Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen receptors. Interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP) are cytokines that engage the IL-7Rα and have major roles in dictating the fate of ILCs. Recent advances in the field have revealed transcriptional programs associated with ILC development and function. In this article, we will review recent studies of the role of IL-7 and TSLP in ILC development and function during infection and inflammation. Frontiers Media S.A. 2019-12-11 /pmc/articles/PMC6917604/ /pubmed/31921158 http://dx.doi.org/10.3389/fimmu.2019.02897 Text en Copyright © 2019 Sheikh and Abraham. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sheikh, Abdalla
Abraham, Ninan
Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title_full Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title_fullStr Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title_full_unstemmed Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title_short Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker
title_sort interleukin-7 receptor alpha in innate lymphoid cells: more than a marker
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917604/
https://www.ncbi.nlm.nih.gov/pubmed/31921158
http://dx.doi.org/10.3389/fimmu.2019.02897
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