The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome

Interleukin-1β (IL-1β) is important for the pathological process of heatstroke (HS), although little is known regarding the main source of the IL-1β produced during the early stage of HS. In this study, heat stress led splenic lymphocytes to death with generation of inflammatory cytokines. The same...

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Detalles Bibliográficos
Autores principales: Wang, Gong, Shen, Tingting, Li, Ping, Luo, Zhen, Tan, Yulong, He, Genlin, Zhang, Xiaoliang, Yang, Ju, Liu, Jun, Wang, Yuan, Tang, He, Luo, Xue, Yang, Xuesen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917643/
https://www.ncbi.nlm.nih.gov/pubmed/31921131
http://dx.doi.org/10.3389/fimmu.2019.02862

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