Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx

Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene mutations which divert cell fate from differentiation to proliferation, HNSCC are considered a heterogeneous group of tumo...

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Detalles Bibliográficos
Autores principales: South, Andrew P., den Breems, Nicoline Y., Richa, Tony, Nwagu, Uche, Zhan, Tingting, Poojan, Shiv, Martinez-Outschoorn, Ubaldo, Johnson, Jennifer M., Luginbuhl, Adam J., Curry, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917707/
https://www.ncbi.nlm.nih.gov/pubmed/31848367
http://dx.doi.org/10.1038/s41598-019-55352-y

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