Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation

A conformational change from normal prion protein(PrP(C)) to abnormal prion protein(PrP(SC)) induces fatal neurodegenerative diseases. Acidic pH is well-known factors involved in the conformational change. Because the protonation of H187 is strongly linked to the change in PrP stability, we examined...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Juhwan, Chang, Iksoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917724/
https://www.ncbi.nlm.nih.gov/pubmed/31848406
http://dx.doi.org/10.1038/s41598-019-55808-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917724/
https://www.ncbi.nlm.nih.gov/pubmed/31848406
http://dx.doi.org/10.1038/s41598-019-55808-1

Ejemplares similares