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Structural insight into conformational change in prion protein by breakage of electrostatic network around H187 due to its protonation
A conformational change from normal prion protein(PrP(C)) to abnormal prion protein(PrP(SC)) induces fatal neurodegenerative diseases. Acidic pH is well-known factors involved in the conformational change. Because the protonation of H187 is strongly linked to the change in PrP stability, we examined...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917724/ https://www.ncbi.nlm.nih.gov/pubmed/31848406 http://dx.doi.org/10.1038/s41598-019-55808-1 |