Cargando…

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V(2) receptor

The neuropeptides oxytocin (OT) and vasopressin (VP) and their G protein-coupled receptors OTR, V(1a)R, V(1b)R, and V(2)R form an important and widely-distributed neuroendocrine signaling system. In mammals, this signaling system regulates water homeostasis, blood pressure, reproduction, as well as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duerrauer, Leopold, Muratspahić, Edin, Gattringer, Jasmin, Keov, Peter, Mendel, Helen C., Pfleger, Kevin D. G., Muttenthaler, Markus, Gruber, Christian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917733/ https://www.ncbi.nlm.nih.gov/pubmed/31848378 http://dx.doi.org/10.1038/s41598-019-55675-w

Ejemplares similares

Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor
por: Muratspahić, Edin, et al.
Publicado: (2021)

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin
por: Dekan, Zoltan, et al.
Publicado: (2021)

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
por: Arrowsmith, Sarah, et al.
Publicado: (2018)

Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling
por: Muratspahić, Edin, et al.
Publicado: (2021)

Harnessing cyclotides to design and develop novel peptide GPCR ligands
por: Muratspahić, Edin, et al.
Publicado: (2020)

Development of a human vasopressin V(1a)-receptor antagonist from an evolutionary-related insect neuropeptide
por: Di Giglio, Maria Giulia, et al.
Publicado: (2017)

Photoswitchable Probes of Oxytocin and Vasopressin
por: Wirth, Ulrike, et al.
Publicado: (2023)

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain
por: Muratspahić, Edin, et al.
Publicado: (2021)

Conformational selection of vasopressin upon V(1a) receptor binding
por: Che, Kateryna, et al.
Publicado: (2021)

Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor
por: Taghizadeh, Mohammad Sadegh, et al.
Publicado: (2022)

Insights into the molecular evolution of oxytocin receptor ligand binding
por: Koehbach, Johannes, et al.
Publicado: (2013)

In vitro Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor
por: Conzelmann, Carina, et al.
Publicado: (2022)

Discovery of Defense- and Neuropeptides in Social Ants by Genome-Mining
por: Gruber, Christian W., et al.
Publicado: (2012)

Physiology of invertebrate oxytocin and vasopressin neuropeptides
por: Gruber, Christian W
Publicado: (2014)

Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
por: Retzl, Bernhard, et al.
Publicado: (2020)

Estimating and mitigating amplification bias in qualitative and quantitative arthropod metabarcoding
por: Krehenwinkel, Henrik, et al.
Publicado: (2017)

Vasopressin and Vasopressin Receptor Antagonists
por: Oh, Yun Kyu
Publicado: (2008)

Pharmacological applications of natural peptide libraries
por: Koehbach, Johannes, et al.
Publicado: (2012)

Isolation of Cysteine-Rich Peptides from Citrullus colocynthis
por: Shahin-Kaleybar, Behzad, et al.
Publicado: (2020)

Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides
por: Hellinger, Roland, et al.
Publicado: (2021)

Temperature effects on pitfall catches of epigeal arthropods: a model and method for bias correction
por: Saska, Pavel, et al.
Publicado: (2013)

Identification of novel arthropod vector G protein-coupled receptors
por: Nowling, Ronald J, et al.
Publicado: (2013)

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias
por: Janovick, Jo Ann, et al.
Publicado: (2017)

Diabetes Diminishes the Portal-Systemic Collateral Vascular Response to Vasopressin via Vasopressin Receptor and G(α) Proteins Regulations in Cirrhotic Rats
por: Lee, Jing-Yi, et al.
Publicado: (2013)

Vasopressin Is No Inotrope
por: Roeleveld, Peter Paul
Publicado: (2018)

The Biology of Vasopressin
por: Sparapani, Samantha, et al.
Publicado: (2021)

Biased Opioid Ligands
por: Faouzi, Abdelfattah, et al.
Publicado: (2020)

Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro
por: Falanga, Chiara Madlen, et al.
Publicado: (2022)

Rethinking Vasopressin: New Insights into Vasopressin Signaling and Its Implications
por: Watts, Jason A., et al.
Publicado: (2023)

Global map of oxytocin/vasopressin-like neuropeptide signalling in insects
por: Liutkeviciute, Zita, et al.
Publicado: (2016)

Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1
por: Shao, Zhehua, et al.
Publicado: (2021)

Exites in Cambrian arthropods and homology of arthropod limb branches
por: Liu, Yu, et al.
Publicado: (2021)

Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking
por: Tiulpakov, Anatoly, et al.
Publicado: (2016)

Biotremology in arthropods
por: Cividini, Sofia, et al.
Publicado: (2020)

Feeding and the Rhodopsin Family G-Protein Coupled Receptors in Nematodes and Arthropods
por: Cardoso, João C.R., et al.
Publicado: (2012)

G6PDH as a key immunometabolic and redox trigger in arthropods
por: Moraes, Bruno, et al.
Publicado: (2023)

The oxytocin receptor signalling system and breast cancer: a critical review
por: Liu, Huiping, et al.
Publicado: (2020)

Discovery of peptide probes to modulate oxytocin-type receptors of insects
por: Keov, Peter, et al.
Publicado: (2018)

Entrapment Bias of Arthropods in Miocene Amber Revealed by Trapping Experiments in a Tropical Forest in Chiapas, Mexico
por: Solórzano Kraemer, Mónica M., et al.
Publicado: (2015)

The effect of DNA degradation bias in passive sampling devices on metabarcoding studies of arthropod communities and their associated microbiota
por: Krehenwinkel, Henrik, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_l4q175hf9l2b8gigv4k95nbj3n