LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma...

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Detalles Bibliográficos
Autores principales: Tang, Fengyuan, Gao, Ruize, Jeevan-Raj, Beena, Wyss, Christof B., Kalathur, Ravi K. R., Piscuoglio, Salvatore, Ng, Charlotte K. Y., Hindupur, Sravanth K., Nuciforo, Sandro, Dazert, Eva, Bock, Thomas, Song, Shuang, Buechel, David, Morini, Marco F., Hergovich, Alexander, Matthias, Patrick, Lim, Dae-Sik, Terracciano, Luigi M., Heim, Markus H., Hall, Michael N., Christofori, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917744/
https://www.ncbi.nlm.nih.gov/pubmed/31848340
http://dx.doi.org/10.1038/s41467-019-13591-7

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