FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels

Radio-fluorogenic (RFG) gels become permanently fluorescent when exposed to high-energy radiation with the intensity of the emission proportional to the local dose of radiation absorbed. An apparatus is described, FluoroTome 1, that is capable of taking a series of tomographic images (thin slices) o...

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Autores principales: Warman, John M., de Haas, Matthijs P., Luthjens, Leonard H., Yao, Tiantian, Navarro-Campos, Julia, Yuksel, Sölen, Aarts, Jan, Thiele, Simon, Houter, Jacco, in het Zandt, Wilco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918256/
https://www.ncbi.nlm.nih.gov/pubmed/31652759
http://dx.doi.org/10.3390/polym11111729
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author Warman, John M.
de Haas, Matthijs P.
Luthjens, Leonard H.
Yao, Tiantian
Navarro-Campos, Julia
Yuksel, Sölen
Aarts, Jan
Thiele, Simon
Houter, Jacco
in het Zandt, Wilco
author_facet Warman, John M.
de Haas, Matthijs P.
Luthjens, Leonard H.
Yao, Tiantian
Navarro-Campos, Julia
Yuksel, Sölen
Aarts, Jan
Thiele, Simon
Houter, Jacco
in het Zandt, Wilco
author_sort Warman, John M.
collection PubMed
description Radio-fluorogenic (RFG) gels become permanently fluorescent when exposed to high-energy radiation with the intensity of the emission proportional to the local dose of radiation absorbed. An apparatus is described, FluoroTome 1, that is capable of taking a series of tomographic images (thin slices) of the fluorescence of such an irradiated RFG gel on-site and within minutes of radiation exposure. These images can then be compiled to construct a 3D movie of the dose distribution within the gel. The historical development via a laboratory-bench prototype to a readily transportable, user-friendly apparatus is described. Instrumental details and performance tests are presented.
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spelling pubmed-69182562019-12-24 FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels Warman, John M. de Haas, Matthijs P. Luthjens, Leonard H. Yao, Tiantian Navarro-Campos, Julia Yuksel, Sölen Aarts, Jan Thiele, Simon Houter, Jacco in het Zandt, Wilco Polymers (Basel) Article Radio-fluorogenic (RFG) gels become permanently fluorescent when exposed to high-energy radiation with the intensity of the emission proportional to the local dose of radiation absorbed. An apparatus is described, FluoroTome 1, that is capable of taking a series of tomographic images (thin slices) of the fluorescence of such an irradiated RFG gel on-site and within minutes of radiation exposure. These images can then be compiled to construct a 3D movie of the dose distribution within the gel. The historical development via a laboratory-bench prototype to a readily transportable, user-friendly apparatus is described. Instrumental details and performance tests are presented. MDPI 2019-10-23 /pmc/articles/PMC6918256/ /pubmed/31652759 http://dx.doi.org/10.3390/polym11111729 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Warman, John M.
de Haas, Matthijs P.
Luthjens, Leonard H.
Yao, Tiantian
Navarro-Campos, Julia
Yuksel, Sölen
Aarts, Jan
Thiele, Simon
Houter, Jacco
in het Zandt, Wilco
FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title_full FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title_fullStr FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title_full_unstemmed FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title_short FluoroTome 1: An Apparatus for Tomographic Imaging of Radio-Fluorogenic (RFG) Gels
title_sort fluorotome 1: an apparatus for tomographic imaging of radio-fluorogenic (rfg) gels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918256/
https://www.ncbi.nlm.nih.gov/pubmed/31652759
http://dx.doi.org/10.3390/polym11111729
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