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Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolact...

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Autores principales: Abid, Zarmeena, Dalskov Mosgaard, Mette, Manfroni, Giorgio, Singh Petersen, Ritika, Hagner Nielsen, Line, Müllertz, Anette, Boisen, Anja, Sylvest Keller, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918296/
https://www.ncbi.nlm.nih.gov/pubmed/31703261
http://dx.doi.org/10.3390/polym11111828
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author Abid, Zarmeena
Dalskov Mosgaard, Mette
Manfroni, Giorgio
Singh Petersen, Ritika
Hagner Nielsen, Line
Müllertz, Anette
Boisen, Anja
Sylvest Keller, Stephan
author_facet Abid, Zarmeena
Dalskov Mosgaard, Mette
Manfroni, Giorgio
Singh Petersen, Ritika
Hagner Nielsen, Line
Müllertz, Anette
Boisen, Anja
Sylvest Keller, Stephan
author_sort Abid, Zarmeena
collection PubMed
description Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks.
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spelling pubmed-69182962019-12-24 Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery Abid, Zarmeena Dalskov Mosgaard, Mette Manfroni, Giorgio Singh Petersen, Ritika Hagner Nielsen, Line Müllertz, Anette Boisen, Anja Sylvest Keller, Stephan Polymers (Basel) Article Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks. MDPI 2019-11-07 /pmc/articles/PMC6918296/ /pubmed/31703261 http://dx.doi.org/10.3390/polym11111828 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abid, Zarmeena
Dalskov Mosgaard, Mette
Manfroni, Giorgio
Singh Petersen, Ritika
Hagner Nielsen, Line
Müllertz, Anette
Boisen, Anja
Sylvest Keller, Stephan
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title_full Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title_fullStr Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title_full_unstemmed Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title_short Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
title_sort investigation of mucoadhesion and degradation of pcl and plga microcontainers for oral drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918296/
https://www.ncbi.nlm.nih.gov/pubmed/31703261
http://dx.doi.org/10.3390/polym11111828
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