Cargando…
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolact...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918296/ https://www.ncbi.nlm.nih.gov/pubmed/31703261 http://dx.doi.org/10.3390/polym11111828 |
_version_ | 1783480558387462144 |
---|---|
author | Abid, Zarmeena Dalskov Mosgaard, Mette Manfroni, Giorgio Singh Petersen, Ritika Hagner Nielsen, Line Müllertz, Anette Boisen, Anja Sylvest Keller, Stephan |
author_facet | Abid, Zarmeena Dalskov Mosgaard, Mette Manfroni, Giorgio Singh Petersen, Ritika Hagner Nielsen, Line Müllertz, Anette Boisen, Anja Sylvest Keller, Stephan |
author_sort | Abid, Zarmeena |
collection | PubMed |
description | Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks. |
format | Online Article Text |
id | pubmed-6918296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69182962019-12-24 Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery Abid, Zarmeena Dalskov Mosgaard, Mette Manfroni, Giorgio Singh Petersen, Ritika Hagner Nielsen, Line Müllertz, Anette Boisen, Anja Sylvest Keller, Stephan Polymers (Basel) Article Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks. MDPI 2019-11-07 /pmc/articles/PMC6918296/ /pubmed/31703261 http://dx.doi.org/10.3390/polym11111828 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Abid, Zarmeena Dalskov Mosgaard, Mette Manfroni, Giorgio Singh Petersen, Ritika Hagner Nielsen, Line Müllertz, Anette Boisen, Anja Sylvest Keller, Stephan Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title | Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title_full | Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title_fullStr | Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title_full_unstemmed | Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title_short | Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery |
title_sort | investigation of mucoadhesion and degradation of pcl and plga microcontainers for oral drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918296/ https://www.ncbi.nlm.nih.gov/pubmed/31703261 http://dx.doi.org/10.3390/polym11111828 |
work_keys_str_mv | AT abidzarmeena investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT dalskovmosgaardmette investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT manfronigiorgio investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT singhpetersenritika investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT hagnernielsenline investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT mullertzanette investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT boisenanja investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery AT sylvestkellerstephan investigationofmucoadhesionanddegradationofpclandplgamicrocontainersfororaldrugdelivery |