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Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice

BACKGROUND: Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. Current therapeutic approaches have primarily aimed to reduce patholog...

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Detalles Bibliográficos
Autores principales:	Davtyan, Hayk, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Antonyan, Tatevik, Coburn, Morgan A., Zagorski, Karen, Chailyan, Gor, Petrushina, Irina, Svystun, Olga, Danhash, Emma, Petrovsky, Nikolai, Cribbs, David H., Agadjanyan, Michael G., Blurton-Jones, Mathew, Ghochikyan, Anahit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918571/ https://www.ncbi.nlm.nih.gov/pubmed/31847886 http://dx.doi.org/10.1186/s13195-019-0556-2

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