Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramp...

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Autores principales: Haller, Sebastian, Kramer, Rolf, Becker, Karsten, Bohnert, Jürgen A, Eckmanns, Tim, Hans, Jörg B, Hecht, Jane, Heidecke, Claus-Dieter, Hübner, Nils-Olaf, Kramer, Axel, Klaper, Kathleen, Littmann, Martina, Marlinghaus, Lennart, Neumann, Bernd, Pfeifer, Yvonne, Pfennigwerth, Niels, Rogge, Simone, Schaufler, Katharina, Thürmer, Andrea, Werner, Guido, Gatermann, Sören
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2019
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918589/
https://www.ncbi.nlm.nih.gov/pubmed/31847948
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.50.1900734
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author Haller, Sebastian
Kramer, Rolf
Becker, Karsten
Bohnert, Jürgen A
Eckmanns, Tim
Hans, Jörg B
Hecht, Jane
Heidecke, Claus-Dieter
Hübner, Nils-Olaf
Kramer, Axel
Klaper, Kathleen
Littmann, Martina
Marlinghaus, Lennart
Neumann, Bernd
Pfeifer, Yvonne
Pfennigwerth, Niels
Rogge, Simone
Schaufler, Katharina
Thürmer, Andrea
Werner, Guido
Gatermann, Sören
author_facet Haller, Sebastian
Kramer, Rolf
Becker, Karsten
Bohnert, Jürgen A
Eckmanns, Tim
Hans, Jörg B
Hecht, Jane
Heidecke, Claus-Dieter
Hübner, Nils-Olaf
Kramer, Axel
Klaper, Kathleen
Littmann, Martina
Marlinghaus, Lennart
Neumann, Bernd
Pfeifer, Yvonne
Pfennigwerth, Niels
Rogge, Simone
Schaufler, Katharina
Thürmer, Andrea
Werner, Guido
Gatermann, Sören
author_sort Haller, Sebastian
collection PubMed
description From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.
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spelling pubmed-69185892020-01-06 Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019 Haller, Sebastian Kramer, Rolf Becker, Karsten Bohnert, Jürgen A Eckmanns, Tim Hans, Jörg B Hecht, Jane Heidecke, Claus-Dieter Hübner, Nils-Olaf Kramer, Axel Klaper, Kathleen Littmann, Martina Marlinghaus, Lennart Neumann, Bernd Pfeifer, Yvonne Pfennigwerth, Niels Rogge, Simone Schaufler, Katharina Thürmer, Andrea Werner, Guido Gatermann, Sören Euro Surveill Rapid Communication From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing. European Centre for Disease Prevention and Control (ECDC) 2019-12-12 /pmc/articles/PMC6918589/ /pubmed/31847948 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.50.1900734 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Haller, Sebastian
Kramer, Rolf
Becker, Karsten
Bohnert, Jürgen A
Eckmanns, Tim
Hans, Jörg B
Hecht, Jane
Heidecke, Claus-Dieter
Hübner, Nils-Olaf
Kramer, Axel
Klaper, Kathleen
Littmann, Martina
Marlinghaus, Lennart
Neumann, Bernd
Pfeifer, Yvonne
Pfennigwerth, Niels
Rogge, Simone
Schaufler, Katharina
Thürmer, Andrea
Werner, Guido
Gatermann, Sören
Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title_full Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title_fullStr Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title_full_unstemmed Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title_short Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
title_sort extensively drug-resistant klebsiella pneumoniae st307 outbreak, north-eastern germany, june to october 2019
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918589/
https://www.ncbi.nlm.nih.gov/pubmed/31847948
http://dx.doi.org/10.2807/1560-7917.ES.2019.24.50.1900734
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