Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

BACKGROUND: Niemann-Pick disease type C (NPC) is a progressive neurodegenerative condition that results in early fatality. NPC is inherited in an autosomal recessive pattern from mutations in NPC1 or NPC2 genes. The etiology of NPC is poorly defined. In that regard, neuroinflammation occurs early in...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Samuel D., Shin, Alexandra, Mayagoitia, Karina, Siebold, Lorraine, Rubini, Marsilio, Wilson, Christopher G., Bellinger, Denise L., Soriano, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918596/
https://www.ncbi.nlm.nih.gov/pubmed/31847862
http://dx.doi.org/10.1186/s12974-019-1663-5

Ejemplares similares

Ejemplares similares