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Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer

BACKGROUND: While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent. To resolve these inconsistencies, we systematically analyzed the available data to determine whether SPP1 and SPP2 are prognostic markers in the co...

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Autores principales: Tu, Yaqin, Chen, Cai, Fan, Guorun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918603/
https://www.ncbi.nlm.nih.gov/pubmed/31849319
http://dx.doi.org/10.1186/s12885-019-6441-3
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author Tu, Yaqin
Chen, Cai
Fan, Guorun
author_facet Tu, Yaqin
Chen, Cai
Fan, Guorun
author_sort Tu, Yaqin
collection PubMed
description BACKGROUND: While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent. To resolve these inconsistencies, we systematically analyzed the available data to determine whether SPP1 and SPP2 are prognostic markers in the context of human cancer. METHODS: The expression of SPP1 and SPP2 was assessed by Oncomine analysis. The PrognoScan database was used to assess the prognostic value of SPP1 and SPP2, with cBioPortal used to assess copy number variations. The STRING database was used to generate a Protein - Protein Interaction (PPI) network for SPP genes. RESULTS: SPP1 was more likely to be over-expressed in breast, bladder, colorectal, head, neck, liver, lung, and esophageal cancers. SPP2 was expressed at lower levels in colorectal cancer, leukemia, liver cancer and pancreatic cancer. In addition, SPP1 and SPP2 mutations mainly occurred in cutaneous melanoma and endometrial cancer. CONCLUSIONS: Our results suggest that SPP1 and SPP2 may be effective therapeutic or diagnostic targets in certain cancers. Further research is required to confirm these results and verify the value of SPP1 and SPP2 as clinical markers of cancer prognosis.
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spelling pubmed-69186032019-12-20 Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer Tu, Yaqin Chen, Cai Fan, Guorun BMC Cancer Research Article BACKGROUND: While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent. To resolve these inconsistencies, we systematically analyzed the available data to determine whether SPP1 and SPP2 are prognostic markers in the context of human cancer. METHODS: The expression of SPP1 and SPP2 was assessed by Oncomine analysis. The PrognoScan database was used to assess the prognostic value of SPP1 and SPP2, with cBioPortal used to assess copy number variations. The STRING database was used to generate a Protein - Protein Interaction (PPI) network for SPP genes. RESULTS: SPP1 was more likely to be over-expressed in breast, bladder, colorectal, head, neck, liver, lung, and esophageal cancers. SPP2 was expressed at lower levels in colorectal cancer, leukemia, liver cancer and pancreatic cancer. In addition, SPP1 and SPP2 mutations mainly occurred in cutaneous melanoma and endometrial cancer. CONCLUSIONS: Our results suggest that SPP1 and SPP2 may be effective therapeutic or diagnostic targets in certain cancers. Further research is required to confirm these results and verify the value of SPP1 and SPP2 as clinical markers of cancer prognosis. BioMed Central 2019-12-18 /pmc/articles/PMC6918603/ /pubmed/31849319 http://dx.doi.org/10.1186/s12885-019-6441-3 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Tu, Yaqin
Chen, Cai
Fan, Guorun
Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title_full Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title_fullStr Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title_full_unstemmed Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title_short Association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
title_sort association between the expression of secreted phosphoprotein - related genes and prognosis of human cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918603/
https://www.ncbi.nlm.nih.gov/pubmed/31849319
http://dx.doi.org/10.1186/s12885-019-6441-3
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